A. Vasudevan

A genetic and physiological model of renal dysfunction in Lowe syndrome

This study uses a Drosophila nephrocyte model to show that OCRL loss causes endolysosomal defects and kidney dysfunction, which can be rescued by human OCRL but not by mutant variants.

Preferential transport of synaptic vesicles across neuronal branches is regulated by the levels of the anterograde motor UNC-104/KIF1A

The paper shows that UNC-104/KIF1A levels regulate synaptic vesicle transport preference in C. elegans neurons, favoring synaptic branches over asynaptic ends.

A human stem cell resource to decipher the biochemical and cellular basis of neurodevelopmental defects in Lowe Syndrome

This study generates human stem cell lines from Lowe Syndrome patients to investigate the cellular and biochemical mechanisms of brain development defects caused by OCRL1 mutations.

Combustible and electronic cigarette exposures increase ACE2 activity and SARS-CoV-2 Spike binding

This study shows that combustible and electronic cigarette exposures increase ACE2 activity and SARS-CoV-2 Spike binding, potentially increasing infection risk.

Cargo crowding, stationary clusters and dynamical reservoirs in axonal transport

This study develops a simulation model of axonal transport in C. elegans touch neurons, showing that stationary vesicle clusters act as dynamic reservoirs that can be regulated to control cargo flux.

NAD+ prevents septic shock-induced death by non-canonical inflammasome blockade and IL-10 cytokine production in macrophages

This study shows NAD+ prevents septic shock by blocking non-canonical inflammasome activation and promoting IL-10 cytokine production in macrophages.

Single chromosome gains can function as metastasis suppressors and metastasis promoters

The paper investigates how single chromosome gains can either suppress or promote metastasis in cancer, showing that specific aneuploidies are linked to distinct clinical outcomes.