Cancer BiologybioRxiv
Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies
D. A. Lukow, E. L. Sausville, P. Suri…·J. M. Sheltzer
This study shows that chromosomal instability accelerates cancer cell adaptation to anti-cancer therapies by enabling specific aneuploidy events that reduce drug sensitivity.
DOI 10.1016/j.devcel.2021.07.009