Author

B. Anand-Apte

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Biochemistry· 2 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cell type annotation· 4 Organism:human· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Assay:imaging· 2 Assay:proteomics· 2 Research Focus:differential expression· 1

Frequent Co-Authors

C. Singh· 3 shared A. Benos· 2 shared A. Grenell· 2 shared J. Sears· 2 shared A. B. Grenell· 1 shared A. L. Engel· 1 shared A. Ramakrishnan· 1 shared A. Wolk· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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3 shared papersBiochemistry

C. Singh

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Tissue Inhibitor of Metalloproteinase 3 (TIMP3) mutations increase glycolytic activity and dysregulate glutamine metabolism in RPE cells

A. B. Grenell, C. Singh, M. Raju, A. Wolk, S. Dalvi, G.-F. Jang, J. S. Crabb, C. E. Hershberger, K. V. Manian, J. W. Crabb, R. Singh, J. Du, B. Anand-Apte

This study shows that TIMP3 mutations in RPE cells increase glycolytic activity and disrupt glutamine metabolism, linking these changes to Sorsbys Fundus Dystrophy.

bioRxiv · Jan 5, 2024Biochemistry

The urea cycle is transcriptionally controlled by hypoxia-inducible factors

C. Singh, A. Benos, A. Grenell, V. Tran, D. Hanna, N. Kannekanti, B. Anand-Apte, H. Brunengraber, J. Sears

The paper shows that HIFs regulate urea cycle genes CPS1 and ARG1, leading to increased urea cycle activity in the liver under hypoxia.

bioRxiv · Jan 25, 2021 · PreprintBiochemistry

Extracellular Matrix Dysfunction in Sorsby Patient-Derived Retinal Pigment Epithelium

A. L. Engel, Y. Wang, T. Khuu, E. Worrall, M. A. Manson, R. R. Lim, K. Knight, A. Yanagida, J. H. Qi, A. Ramakrishnan, R. G. Weleber, M. Klein, D. J. Wilson, B. Anand-Apte, J. B. Hurley, , J. R. Chao

This study examines SFD patient-derived iPSC-RPE for extracellular matrix dysfunction and oxidative stress, finding increased sub-RPE deposits and elevated 4-hydroxyproline levels.

bioRxiv · Jan 6, 2021Cell Biology

Hyperoxia inhibits proliferation of retinal endothelial cells in Myc dependent manner

C. Singh, A. Benos, A. Grenell, S. Rao, B. Anand-Apte, J. Sears

The paper shows hyperoxia inhibits retinal endothelial cell proliferation via Myc dependency, contributing to oxygen-induced retinopathy.

bioRxiv · Nov 9, 2020Cell Biology

Primary cilia are present on endothelial cells of the hyaloid vasculature but are not required for the development of the blood-retinal barrier

L. M. Pollock, B. Perkins, B. Anand-Apte

The paper investigates whether endothelial cilia are required for blood-retinal barrier development in zebrafish, finding that cilia are present but not necessary for barrier integrity.

bioRxiv · Nov 5, 2019Cell Biology

Prolonged Ocular Exposure Leads to the Formation of Retinal Lesions in Mice

B. A. Bell, V. Bonilha, S. Hagstrom, B. Anand-Apte, J. G. Hollyfield, I. Samuels

This study investigates retinal lesion formation in mice following prolonged ocular exposure during anesthesia recovery, finding that unprotected eyes in open chambers develop significant lesions, while protected eyes show no complications.

bioRxiv · Feb 19, 2019Pathology