J. L. Feldman

Somatic polyploidy supports biosynthesis and tissue function by increasing transcriptional output

The paper shows that polyploidy in C. elegans intestine increases transcriptional output and supports biosynthesis by compensating for mRNA dilution through increased RNA Polymerase II loading.

MAP9/MAPH-9 supports axonemal microtubule doublets and modulates motor movement

This study identifies MAP9/MAPH-9 as a conserved protein supporting axonemal microtubule doublets and modulating ciliary motor function in C. elegans and mammals.

Proximity labeling at non-centrosomal microtubule-organizing centers reveals VAB-10B and WDR-62 as distinct microtubule regulators

The paper identifies VAB-10B and WDR-62 as distinct regulators of non-centrosomal microtubules using proximity labeling in C. elegans.

Centriole-less pericentriolar material serves as a microtubule organizing center at the base of C. elegans sensory cilia

The paper identifies a centriole-less pericentriolar material (PCM) in C. elegans sensory cilia that functions as a microtubule organizing center (MTOC) independent of centrioles.

A two-step mechanism for the inactivation of microtubule organizing center function at the centrosome

The paper identifies a two-step mechanism for centrosome inactivation as an MTOC, involving phosphatase-dependent PCM dissolution and cortical force-mediated PCM ejection.

Tissue-specific degradation of essential centrosome components reveals distinct microtubule populations at microtubule organizing centers

The paper investigates the role of centrosomal components in microtubule organization by degrading them tissue-specifically in C. elegans, revealing distinct microtubule populations at different MTOCs.

Directed evolution of TurboID for efficient proximity labeling in living cells and organisms

The paper develops TurboID and miniTurbo, biotin ligase mutants with enhanced catalytic efficiency for proximity labeling in cells and organisms, significantly reducing labeling time and toxicity.

Inhaled nicotine equivalent to cigarette smoking disrupts systemic and uterine hemodynamics and induces cardiac arrhythmia in pregnant rats

This study shows that inhaled nicotine during pregnancy disrupts systemic and uterine hemodynamics and causes cardiac arrhythmia in rats, with effects blocked by a nicotinic receptor antagonist.