M. P. Swaffer

Somatic polyploidy supports biosynthesis and tissue function by increasing transcriptional output

The paper shows that polyploidy in C. elegans intestine increases transcriptional output and supports biosynthesis by compensating for mRNA dilution through increased RNA Polymerase II loading.

Genome dilution by cell growth drives starvation-like proteome remodeling in mammalian and yeast cells

The paper shows that increasing cell size leads to proteome remodeling similar to starvation, driven by genome dilution in mammalian and yeast cells.

Increasing cell size remodels the proteome and promotes senescence

The paper shows that increasing cell size remodels the proteome and promotes senescence, but polyploidization can prevent this by altering the DNA-to-ploidy ratio.

Localized phosphorylation of RNA Polymerase II by G1 cyclin-Cdk promotes cell cycle entry

The paper shows that G1 cyclin-Cdk phosphorylates RNA Polymerase II at SBF-regulated promoters to activate transcription and promote cell cycle entry.

Size-independent mRNA synthesis and chromatin-based partitioning mechanisms generate and maintain constant amounts of protein per cell

The paper identifies transcriptional and chromatin-based mechanisms that generate and maintain constant protein amounts per cell despite changes in cell size.