T. Stearns

MAP9/MAPH-9 supports axonemal microtubule doublets and modulates motor movement

This study identifies MAP9/MAPH-9 as a conserved protein supporting axonemal microtubule doublets and modulating ciliary motor function in C. elegans and mammals.

Spindle assembly checkpoint-dependent mitotic delay is required for cell division in absence of centrosomes

The paper shows that SAC-dependent mitotic delay is necessary for bipolar division in acentrosomal cells, but not for polyploidy.

Distinct Tumor Necrosis Factor Alpha Receptors Dictate Stem Cell Fitness Versus Lineage Output in Dnmt3a-Mutant Clonal Hematopoiesis

The paper investigates how distinct TNF receptors influence mutant HSC fitness and lineage output in Dnmt3a-mutant clonal hematopoiesis, showing independent regulation of clone size and cell type production.

Calcineurin associates with centrosomes and regulates cilia length maintenance

This study identifies calcineurin's association with centrosomes and its role in regulating cilia length maintenance through interaction with POC5.

Post-mitotic centriole disengagement and maturation leads to centrosome amplification in polyploid trophoblast giant cells

The paper examines centriole and centrosome dynamics in trophoblast giant cells during endocycles, finding that centrioles disengage and convert to centrosomes, increasing their number but not as much as DNA replication.

Long-range migration of centrioles to the apical surface of the olfactory epithelium

This study investigates how centrioles migrate from progenitor cells to the apical surface in olfactory sensory neurons, finding they move in groups and are associated with microtubule factors.

The nucleus serves as the pacemaker for the cell cycle

The study shows mitosis initiates in the nucleus and spreads outward in circular trigger waves in Xenopus egg extracts, suggesting the nucleus acts as a pacemaker for the cell cycle.

Systematic discovery of Short Linear Motifs decodes calcineurin phosphatase signaling

The paper identifies calcineurin (CN) substrates and interactors using a combination of experimental and computational methods, revealing novel roles for CN in regulating nuclear pore complex proteins.

Transient primary cilia mediate robust Hedgehog pathway-dependent cell cycle control

This study shows that primary cilia in mouse medulloblastoma cells mediate Hedgehog pathway-dependent cell cycle control by allowing Hh signaling during two distinct phases of the cell cycle.

Centrioles are amplified via rosette formation in cycling progenitors of olfactory sensory neurons

The paper shows that centrioles are amplified through rosette formation in olfactory sensory neuron progenitors during development and adult epithelium turnover, with Plk4 and Stil mRNA elevation involved.

Aging-Associated Decrease in the Histone Acetyltransferase KAT6B Causes Myeloid-Biased Hematopoietic Stem Cell Differentiation

This study shows that aging reduces KAT6B, an epigenetic regulator, leading to myeloid-biased differentiation of hematopoietic stem cells.

Primary Cilium Disassembly in Mammalian Cells Occurs Predominantly by Whole-Cilium Shedding

This study shows that mammalian primary cilia disassemble mainly by shedding the entire cilium, with some gradual resorption, and identifies katanin as a key regulator of this process.

Regulation of Cilia Abundance in Multiciliated Cells

This study shows that centriole and cilia abundance in multiciliated cells is controlled by surface area, not parental centrioles or Plk4.

Revealing the nanoscale morphology of the primary cilium using super-resolution fluorescence microscopy

This study uses super-resolution microscopy and computational methods to quantify nanoscale morphology changes in primary cilia under different treatments.

Centriole triplet microtubules are required for stable centriole formation and inheritance in human cells

This study shows that delta-tubulin and epsilon-tubulin are essential for stable centriole formation and inheritance in human cells by maintaining triplet microtubules.