K. Guo

Labeling Natural Killer cells with superparamagnetic iron oxide nanoparticles for detection by preclinical and clinical-scale magnetic particle imaging

This study labels NK cells with iron oxide nanoparticles and demonstrates their detection using magnetic particle imaging in preclinical and clinical settings.

Functional Diversification of Gene Duplicates under the Constraint of Protein Structure

This study examines gene duplication and divergence in GH50 agarases from Agarivorans ablus, showing structural and functional divergence while maintaining conserved backbone structures.

Synthesis of arbitrary interference patterns using a single galvanometric mirror, and its application to Structured Illumination Microscopy

The paper introduces SWIFT, a new interferometer that projects arbitrary interference patterns using a single galvanometric mirror, and applies it to 2D and 3D Structured Illumination Microscopy.

High Shear Stress Reduces ERG Causing Endothelial-Mesenchymal Transition and Pulmonary Arterial Hypertension

The paper shows high shear stress induces endothelial-mesenchymal transition and pulmonary arterial hypertension by reducing ERG expression, which can be mitigated by ERG replenishment.

A removable and cosmopolitan dsRNA Toti-like virus causes latent infection in a model diatom strain

The paper identifies a dsRNA Totiviridae virus in two diatom strains, shows it can be removed to create virus-free lines, and suggests it causes latent infection rather than lytic infection.

An Artificial Intelligence-Assisted Digital Microfluidic System for Multistate Droplet Control

This paper introduces an AI-assisted digital microfluidic system called DropAI for multistate droplet control using semantic segmentation and state machine feedback.

BNIP3-mediated mitophagy boosts the competitive dominant growth of lenvatinib resistant cells via reprogramming energy metabolism in HCC

This study identifies BNIP3-mediated mitophagy as a mechanism enhancing lenvatinib-resistant HCC cells' competitive growth through energy metabolism reprogramming.

Colocalization of Protein and microRNA Markers Reveals Unique Extracellular Vesicle Sub-Populations for Early Cancer Detection

This study introduces NOBEL-SPA to analyze EV sub-populations by colocalizing protein and miRNA markers, identifying unique signatures for early breast cancer detection.

Hyperspectral Oblique Plane Microscopy Enables Spontaneous, Label-Free Imaging of Biological Dynamic Processes in Live Animals

This paper introduces a new microscope, λ-OPM, that enables fast, label-free imaging of biological processes in live zebrafish embryos using Raman spectroscopy.

Spatiotemporal cell landscape of human embryonic tooth development

The paper maps the spatiotemporal cell landscape of human embryonic tooth development using single-cell RNA sequencing and spatial transcriptomics, identifying key cell types and regulatory networks.

Efficient megakaryopoiesis and platelet production require phospholipid remodeling and PUFA uptake through CD36

This study identifies the role of phospholipid remodeling and PUFA uptake via CD36 in megakaryopoiesis and platelet production, showing dietary fatty acids impact platelet counts.

A therapeutic hepatitis B mRNA vaccine with strong immunogenicity and persistent virological suppression

This paper develops an mRNA vaccine for chronic hepatitis B that shows strong immunogenicity and persistent virological suppression in mouse models.

Inflammation-mediated Upregulation of VCAM-1 but not KIM-1 during Acute Kidney Injury to Chronic Kidney Disease Transition

This study identifies VCAM-1 upregulation as a key marker of AKI-to-CKD transition, distinct from KIM-1, through mouse models and human single-cell transcriptomics.

Vitamin K-dependent carboxylation regulates calcium flux and adaptation to metabolic stress in β-cells

This study shows that vitamin K-dependent gamma-carboxylation in beta-cells regulates calcium flux and adaptation to metabolic stress by modulating ERGP function.

SER: an R package to compute environmental regime over a certain time period

SER computes environmental regimes over time periods to improve understanding of environmental impacts on ecological communities and other fields.

TFAM-dependent mitochondrial integrity in regulatory T cells preserves immune landscape and restrains inflammaging

This study identifies TFAM-dependent mitochondrial integrity in Tregs as critical for preserving immune homeostasis and preventing inflammaging.

The chemokine receptor CXCR3 promotes CD8+ T cell-dependent lung pathology during influenza pathogenesis

The paper identifies CXCR3-expressing CD8+ T cells as a driver of lung pathology during influenza infection without affecting viral clearance.

Cellular heterogeneity and molecular reprogramming of host response during influenza acute lung injury

This study uses scRNA-seq to analyze lung cellular heterogeneity and host response during severe influenza infection in mice, identifying key immune and non-immune cell changes and communication dynamics.

Recovery from acute SARS-CoV-2 infection and development of anamnestic immune responses in T cell-depleted rhesus macaques

This study shows that T cell depletion in rhesus macaques does not cause severe SARS-CoV-2 disease but delays viral clearance, and T cells are not essential for immunological memory or protection against re-infection.

Interferon Resistance of Emerging SARS-CoV-2 Variants

This study shows emerging SARS-CoV-2 variants are more resistant to human interferons, suggesting innate immune evasion plays a key role in their evolution.

Somatic Mutations in Collagens are Associated with a Distinct Tumor Environment and Overall Survival in Gastric Cancer

This study identifies somatic collagen mutations in gastric cancer linked to distinct tumor environments and survival outcomes.

Half of the world's tree biodiversity is unprotected and is increasingly threatened by human activities

The paper identifies priority areas for global tree conservation and finds that half are unprotected and face human threats.

MATE-Seq: Microfluidic Antigen-TCR Engagement Sequencing

MATE-Seq identifies antigen-specific T-cell receptors by isolating and sequencing T-cells bound to peptide-MHC tetramers with high sensitivity.

Fruit performance of kiwifruit in the loess area of Northwest China

The paper investigates how soil properties affect kiwifruit quality in Northwest China, finding specific soil factors influence different fruit quality traits.

The Population Genetic Variation Analysis of Bitter Gourd Wilt Caused by Fusarium oxysporum f. sp. momordicae in China by Inter Simple Sequence Repeats (ISSR) Molecular Marker

The paper analyzes genetic variation in Fusarium oxysporum f. sp. momordicae isolates from China using ISSR markers, revealing low genetic diversity and significant population differentiation.

Uncharacterized bacterial structures revealed by electron cryotomography

The paper presents uncharacterized bacterial structures observed via electron cryotomography to encourage their identification and study.