Author

J. Langer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 5 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Assay:cryo-EM· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:protein structure prediction· 2 Assay:structural biology· 2

Frequent Co-Authors

J. Meier-Credo· 2 shared A. J. Sodt· 1 shared A. Ma· 1 shared A. Neuhaus· 1 shared A. S. Frangakis· 1 shared A. Typas· 1 shared B. Averhoff· 1 shared B. Daum· 1 shared

Activity by Year

2019-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 5 mutual co-author links

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2 shared papersBiophysics

J. Meier-Credo

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Author profile →

7 papers

Recent·Most cited

Structural and biochemical analysis of ligand binding in yeast Niemann-Pick type C1-related protein

L. Nel, K. Thaysen, D. Jamecna, E. Olesen, M. Szomek, J. Langer, K. M. Frain, D. Hoeglinger, D. Wustner, B. P. Pedersen

This study investigates the lipid binding properties of the yeast NCR1/NPC2 system using crystal structures and binding assays, revealing its ability to bind multiple lipids beyond sterols.

bioRxiv · Jun 10, 2024Biophysics

Magnesium Transporter MgtA revealed as a Dimeric P-type ATPase

R. Zeinert, F. Zhou, P. H. C. Franco, J. Zoeller, H. Lessen, L. Aravind, J. Langer, A. J. Sodt, G. Storz, D. Matthies

The paper reports the first structure of the Mg2+ transporter MgtA using cryo-EM, revealing its dimeric form and mechanism of Mg2+ transport.

bioRxiv · Feb 28, 2024 · PreprintBiophysics

The killing of human gut commensal E. coli ED1a by tetracycline is associated with severe ribosome dysfunction

I. Khusainov, N. Romanov, C. Goemans, B. Turonova, C. E. Zimmerli, S. Welsch, J. Langer, A. Typas, M. Beck

The paper examines how tetracycline affects ribosome function in two E. coli strains, showing different outcomes based on the antibiotic's bacteriostatic or bactericidal effect.

bioRxiv · Jul 6, 2023Biophysics

Characterization of the cytopathic effect of monkeypox virus isolated from clinical specimens and differentiation from common viral exanthems

A. Ma, K. E. Hanson, J. Langer, B. T. Bradley

The paper characterizes the cytopathic effect of monkeypox virus from clinical samples and differentiates it from other viral exanthems using cell culture.

bioRxiv · Sep 13, 2022Microbiology

The immunodominant protein P116 extracts cholesterol and other essential lipids

L. Sprankel, D. Vizarraga, J. Martin, S. Manger, J. Meier-Credo, M. Marcos, J. Julve, N. Rotllan, M. P. Scheffer, J. C. Escola-Gil, J. Langer, J. Pinyol, I. Fita, A. S. Frangakis

This paper identifies P116 as a lipid-extracting protein from Mycoplasma pneumoniae, revealing its structural mechanism for extracting cholesterol and other lipids from host environments.

bioRxiv · Jun 28, 2022 · PreprintBiophysics

Conformational changes in mitochondrial complex I from the thermophilic eukaryote Chaetomium thermophilum

E. Laube, J. Meier-Credo, J. Langer, W. Kuehlbrandt

This study reports the cryoEM structure of mitochondrial complex I from Chaetomium thermophilum, revealing conformational changes that suggest a conserved mechanism of electron transport and proton pumping.

bioRxiv · May 13, 2022Biochemistry

A new twist on bacterial motility - Two distinct type IV pili revealed by cryoEM

A. Neuhaus, M. Selvaraj, R. Salzer, J. Langer, K. Kruse, K. Sanders, B. Daum, B. Averhoff, V. Gold

This study identifies two distinct type IV pili in Thermus thermophilus using cryoEM, revealing their structural differences and functional roles in motility and DNA uptake.

bioRxiv · Aug 12, 2019Biophysics