Author

J. Leal

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:drug response / drug discovery· 3 Organism:human· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Assay:organoid / primary culture· 1

Frequent Co-Authors

D. Ghosh· 4 shared T. Dong· 3 shared X. Peng· 3 shared D. Arasappan· 2 shared D. C. Wylie· 2 shared H. D. Smyth· 2 shared R. Mohanty· 2 shared X. Liu· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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4 shared papersBioengineering

D. Ghosh

Mutual co-authors in cluster

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5 papers

Recent·Most cited

Discovery of peptides for targeted delivery of mRNA lipid nanoparticles to cystic fibrosis lung epithelia

M. R. Soto, M. M. Lewis, J. Leal, Y. Pan, R. P. Mohanty, X. Peng, T. Dong, D. Ghosh

The paper identifies a peptide that enhances mRNA lipid nanoparticle delivery to CF lung epithelial cells, showing improved mRNA expression in vitro and in vivo.

bioRxiv · Sep 13, 2023 · PreprintBioengineering

Bioelectronic microfluidic wound healing

S. W. Shaner, A. Savelyeva, A. Kvartuh, N. Jedrusik, L. Matter, J. Leal, M. Asplund

This study shows that DC electric fields enhance wound closure in both healthy and diabetic keratinocyte models by up to 3X.

bioRxiv · Jul 8, 2022Bioengineering

Identification of peptide coatings that enhance diffusive transport of nanoparticles through the tumor microenvironment

R. Mohanty, X. Liu, J. Y. Kim, X. Peng, S. Bhandari, J. Leal, D. Arasappan, D. C. Wylie, T. Dong, D. Ghosh

The paper identifies a peptide coating that enhances nanoparticle diffusion through the tumor microenvironment by screening phage libraries and testing transport in vitro and ex vivo.

bioRxiv · Jun 4, 2019Bioengineering

A combinatorial biomolecular strategy to identify peptides for improved transport across the sputum of cystic fibrosis patients and the underlying epithelia

J. Leal, X. Liu, X. Peng, R. Mohanty, D. Arasappan, D. C. Wylie, S. H. Schwartz, J. J. Fullmer, B. C. McWilliams, H. D. Smyth, D. Ghosh

The paper identifies peptides that enhance drug delivery through mucus and epithelial barriers in CF patients using phage libraries and sequencing.

bioRxiv · Jun 4, 2019 · PreprintBioengineering

M13 phage display to identify a permeating peptide against hyperconcentrated mucin

J. Leal, T. Dong, F. Gao, M. Soto, H. D. Smyth, D. Ghosh

The paper uses M13 phage display to identify a neutral, hydrophilic peptide that enhances permeation through hyperconcentrated mucin.

bioRxiv · Jun 4, 2019 · PreprintBioengineering