T. Dong

Amidase and Lysozyme Dual Functions in TseP Reveal a New Family of Chimeric Effectors in the Type VI Secretion System

This paper identifies TseP as a dual amidase-lysozyme T6SS effector with potential for combating antimicrobial resistance.

LLPS condensates of Fha initiate the inside-out assembly of the type VI secretion system

This study identifies Fha as the initiator of T6SS assembly in Acidovorax citrulli, showing it forms LLPS condensates that recruit T6SS components, revealing an inside-first assembly model.

Presence of NCOR1+/CD4+ T cells in tertiary lymphoid organ predicts favorable prognosis in pancreatic ductal adenocarcinoma

The paper shows that NCOR1+/CD4+ T cells in tertiary lymphoid organs predict better outcomes in pancreatic ductal adenocarcinoma patients.

Proximity proteomics reveals UCH-L1 as an NLRP3 interactor that modulates IL-1β production in human macrophages and microglia

The paper identifies UCH-L1 as an NLRP3 interactor that modulates IL-1β production in human macrophages and microglia through proximity proteomics and functional assays.

Computational design of N-linked glycans for high throughput epitope profiling

The paper develops a computational method using N-linked glycans to rapidly map epitopes, validated through ELISA, yeast display, and X-ray crystallography using human coagulation factor IXa.

Discovery of peptides for targeted delivery of mRNA lipid nanoparticles to cystic fibrosis lung epithelia

The paper identifies a peptide that enhances mRNA lipid nanoparticle delivery to CF lung epithelial cells, showing improved mRNA expression in vitro and in vivo.

Activation of peroxisome proliferator-activated receptor-gamma prevents monocrotaline-induced pulmonary arterial hypertension by suppressing of nuclear factor-kappa B mediated autophagy

This study shows that activating PPAR-gamma reduces pulmonary arterial hypertension by inhibiting NF-kappa B-mediated autophagy in a rat model.

Two haplotype-resolved genomes of highly heterozygous AAB allotriploid bananas provide insights into subgenome asymmetric evolution and banana wilt control

This study presents haplotype-resolved genomes of triploid bananas, revealing subgenome asymmetric evolution and resistance mechanisms against banana wilt.

Large clones of pre-existing T cells drive early immunity against SARS-COV-2 and LCMV infection.

The paper identifies high frequency naive T cell precursors that drive rapid T cell responses during early SARS-COV-2 and LCMV infections.

Systematic mutagenesis reveals critical effector functions in the assembly and dueling of the H1-T6SS in Pseudomonas aeruginosa

This study systematically mutagenizes H1-T6SS effectors and VgrG proteins in Pseudomonas aeruginosa to reveal their roles in T6SS assembly and dueling responses.

A dueling-competent signal-sensing module guides precise delivery of cargo proteins into target cells by engineered Pseudomonas aeruginosa

This paper introduces a protein delivery platform called DUEC that selectively delivers cargo into target cells using engineered bacterial systems.

Automated assembly of high-density carbon fiber electrode arrays for single unit electrophysiological recordings

This paper introduces a machine for automated assembly of high-density carbon fiber electrode arrays, achieving precise placement and demonstrating successful single unit electrophysiological recordings in rats.

SARS-CoV-2 mutations affect proteasome processing to alter CD8+ T cell responses

The paper investigates how mutations in flanking regions of SARS-CoV-2 nucleoprotein epitopes affect proteasome processing and CD8+ T cell responses, finding some mutations reduce responses while others enhance them.

IFITM3 regulates virus-induced inflammatory cytokine production by titrating Nogo-B orchestration of TLR responses

This study shows IFITM3 limits viral pathogenesis by regulating Nogo-B-mediated TLR responses and cytokine production in dendritic cells.

Breaching the cell-envelope barriers of gram-positive and fungal microbes by a type VI secretion system in Acidovorax citrulli

This study identifies a type VI secretion system in Acidovorax citrulli that can breach gram-positive and fungal cell envelopes, with RhsB as a key effector.

Synthetic antigen presenting cells reveal the diversity and functional specialisation of extracellular vesicles composing the fourth signal of T cell immunological synapses.

This study uses synthetic antigen-presenting cells to analyze the composition and functional specialization of extracellular vesicles released during T cell immunological synapses.

Abiotic factors modulate interspecies competition mediated by the type VI secretion system effectors in Vibrio cholerae

This study shows that abiotic factors like cations and temperature influence the effectiveness of Vibrio cholerae's type VI secretion system effectors in interspecies competition.

The impact of viral mutations on recognition by SARS-CoV-2 specific T-cells

The paper identifies SARS-CoV-2 T-cell epitope variants that reduce recognition by T-cells, highlighting the risk of immune evasion.

Benchtop Carbon Fiber Microelectrode Array Fabrication Toolkit

This paper describes a low-cost, benchtop method for fabricating carbon fiber microelectrode arrays with improved tip optimization techniques.

Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV

This study examines SARS-CoV-2-specific immune responses in people living with HIV on ART, finding comparable antibody and T cell responses to HIV-negative individuals, with T cell magnitude linked to CD4 T cell pool size and CD4:CD8 ratio.

Role of YAP1 gene in proliferation and osteogenic differentiation of human periodontal ligament stem cells induced by TNF-α

This study investigates the role of YAP1 in TNF-α-induced proliferation and osteogenic differentiation of human periodontal ligament stem cells, finding that YAP1 enhances cell proliferation and differentiation via the Hippo signaling pathway.

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent COVID-19 patients.

This study examines T cell immunity in UK COVID-19 patients, finding stronger and broader memory T cell responses in severe cases, with implications for vaccine design.

Low basal expression and slow induction of IFITM3 puts immune cells at risk of influenza A infection

This study shows that low basal expression and slow induction of IFITM3 in immune cells increases their susceptibility to influenza A virus infection.

Broadly inhibiting anti-neuraminidase monoclonal antibodies induced by trivalent influenza vaccine and H7N9 infection in humans

This study identifies broadly reactive human monoclonal antibodies against N1 neuraminidase from vaccination and H7N9 infection, showing cross-inhibition of diverse N1 NAs and protective efficacy in mice.

Identification of peptide coatings that enhance diffusive transport of nanoparticles through the tumor microenvironment

The paper identifies a peptide coating that enhances nanoparticle diffusion through the tumor microenvironment by screening phage libraries and testing transport in vitro and ex vivo.

M13 phage display to identify a permeating peptide against hyperconcentrated mucin

The paper uses M13 phage display to identify a neutral, hydrophilic peptide that enhances permeation through hyperconcentrated mucin.

Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T-cells

The paper identifies synaptic ectosomes released by helper T cells that contain TCR and CD40L, enabling dendritic cell maturation and cytokine production.

Factors Associated with Scientific Misconduct and Questionable Research Practices in Health Professions Education

This study identifies factors associated with scientific misconduct and questionable research practices in health professions education, finding that publication pressure and number of publications are positively linked to misconduct frequency.

Distinct antibody-mediated selection in a narrow-source HIV-1 outbreak among Chinese former plasma donors

The paper analyzes HIV-1 envelope gp120 evolution in Chinese former plasma donors to identify antibody epitopes under immune selection, finding five sites under positive selection and four novel epitopes.

Wikipedia as a gateway to biomedical research: The relative distribution and use of citations in the English Wikipedia

The paper analyzes DOI citation referral rates from Wikipedia, finding higher citation density on medical pages but no evidence of higher referral rates.