Author

J. Lorens

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1

Frequent Co-Authors

J. E. Toombs· 2 shared N. Z. Phinney· 2 shared R. A. Brekken· 2 shared A. Mai· 1 shared A. Molven· 1 shared A. Rizvi· 1 shared A. Rulina· 1 shared C. E. Tiron· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersCancer Biology

J. E. Toombs

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

AXL-TBK1 driven nuclear AKT3 promotes metastasis

E. N. Arner, J. M. Westcott, S. Hinz, C. E. Tiron, M. Blo, A. Mai, R. Virtakoivu, N. Z. Phinney, S. Nord, K. Y. Aguilera, A. Rizvi, J. E. Toombs, T. Reese, V. Fey, D. Micklem, , R. A. Brekken

This study identifies AXL-TBK1-driven nuclear AKT3 as a driver of EMT and metastasis, showing that selective AKT3 inhibition reduces tumor progression in breast cancer.

bioRxiv · Jan 17, 2022 · PreprintCancer Biology

C/EBPB-dependent Adaptation to Palmitic Acid Promotes Stemness in Hormone Receptor Negative Breast Cancer

X. Liu, A. Rulina, M. H. Choi, L. Pedersen, J. Lepland, S. Takle, N. Madeleine, S. Peters, C. E. Wogsland, S. M. Grondal, J. Lorens, H. Goodarzi, A. Molven, P. E. Lonning, S. Knappskog, N. Halberg

The paper shows obesity-induced palmitic acid drives tumor initiation in hormone receptor negative breast cancer through C/EBPB-dependent transcriptional networks.

bioRxiv · Aug 11, 2020Cancer Biology

AXL is a key factor for cell plasticity and promotes metastasis in pancreatic cancer

W. Du, H. Huang, Z. Wang, J. E. Toombs, N. Z. Phinney, Y. Zhang, M. S. Beg, T. M. Wilkie, J. Lorens, R. A. Brekken

This study identifies AXL as a key driver of cell plasticity and metastasis in pancreatic cancer using single-cell RNA sequencing and mouse models.

bioRxiv · Jul 6, 2020Cancer Biology

Microenvironment-contextual cell signaling is attenuated with age

H. Ertsas, M. LaBarge, J. Lorens

The paper investigates age-related changes in microenvironmental signaling in human mammary epithelial cells and finds attenuated ECM-mediated signaling and altered integrin activation in older cells.

bioRxiv · Jun 27, 2019 · PreprintCell Biology