Cancer BiologybioRxiv
p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs
J. L. Grit, L. E. McGee, E. A. Tovar…·M. Steensma
This study shows p53 loss in NF1-related MPNSTs leads to MET instability, kinome reprogramming, and therapy resistance through altered signaling and lineage plasticity.
DOI 10.1038/s41388-024-03000-9