C. J. Essenburg

This study investigates how NF1 deficiency affects metabolic reprogramming in ER+ breast cancer and identifies potential therapeutic synergies between metabolic and targeted inhibitors.

This study shows that Nf1 deficiency in rats increases mammary collagen and restricts adipocyte differentiation before tumor formation, suggesting a role in breast cancer risk.

This study shows p53 loss in NF1-related MPNSTs leads to MET instability, kinome reprogramming, and therapy resistance through altered signaling and lineage plasticity.

This study shows that Nf1 deficiency in rats accelerates mammary development and promotes luminal-basal plasticity and EMT-mediated invasion.

This study shows NF1 deficiency in breast cancer correlates with estrogen receptor signaling and poor survival, using rat models and human genomic data.