p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs
J. L. Grit, L. E. McGee, E. A. Tovar, C. J. Essenburg, E. Wolfrum, I. Beddows, K. Williams, R. Sheridan, J. Schipper, M. Adams, M. Arumugam, T. Vander Woude, S. Gurunathan, J. M. Field, J. Wulfkuhle, , M. Steensma
This study shows p53 loss in NF1-related MPNSTs leads to MET instability, kinome reprogramming, and therapy resistance through altered signaling and lineage plasticity.
bioRxiv · Jan 18, 2023Cancer Biology