Author

E. Wolfrum

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Biochemistry· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:differential expression· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

C. J. Essenburg· 3 shared C. R. Graveel· 3 shared E. A. Tovar· 3 shared K. Williams· 2 shared M. Arumugam· 2 shared Z. B. Madaj· 2 shared A. Bergsma· 1 shared A. Drougard· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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3 shared papersCancer Biology

C. J. Essenburg

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Developmental priming of cancer susceptibility

I. Panzeri, L. Fagnocchi, S. Apostle, M. Tompkins, E. Wolfrum, Z. Madaj, G. Hostetter, Y. Liu, K. Schaefer, C.-H. Yang, A. Bergsma, A. Drougard, E. Dror, PERMUTE, D. Chandler, , J. A. Pospisilik

The paper shows that early life epigenetic variation can prime cancer-susceptibility states that persist into adulthood and correlate with poor prognosis in human cancers.

Nature Cancer · Jan 24, 2025Peer-reviewedCancer Biology

A diverse proteome is present and enzymatically active in metabolite extracts

R. J. House, M. T. Soper-Hopper, M. P. Vincent, A. E. Ellis, C. D. Capan, Z. B. Madaj, E. Wolfrum, C. Isaguirre, C. D. Castello, A. Johnson, M. L. Escobar Galvis, K. Williams, H. Lee, R. D. Sheldon

The paper shows that metabolite extracts contain active enzymes and demonstrates a new workflow to remove proteins for improved metabolomics.

Nature Communications · Jul 10, 2024Peer-reviewedBiochemistry

Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases

A. Shemorry, W. den Besten, M. M. Mulvihill, C. J. Essenburg, N. Blaquiere, T. Kleinheinz, E. Villemure, F. Peale, G. Deshmukh, D. Maddalo, E. Levy, K. Yu, E. A. Tovar, E. Wolfrum, R. A. Blake, , I. E. Wertz

This study evaluates bifunctional ER degraders with different ubiquitin ligase ligands, finding that pan-IAP antagonists enhance ER degradation and induce TNF-dependent cell death more effectively than existing therapies.

bioRxiv · Jun 9, 2024Cancer Biology

Nf1 Deficiency Increases Mammary Collagen Deposition and Restricts Adipocyte Differentiation Before Tumor Formation

M. Arumugam, E. A. Tovar, C. J. Essenburg, P. S. Dischinger, I. T. Beddows, E. Wolfrum, Z. B. Madaj, L. Turner, K. Feenstra, K. L. Gallik, L. Cohen, M. Nichols, R. T. Sheridan, C. R. Esquibel, G. Mouneimne, , M. R. Steensma

This study shows that Nf1 deficiency in rats increases mammary collagen and restricts adipocyte differentiation before tumor formation, suggesting a role in breast cancer risk.

bioRxiv · Jun 1, 2023 · PreprintCancer Biology

p53 modulates kinase inhibitor resistance and lineage plasticity in NF1-related MPNSTs

J. L. Grit, L. E. McGee, E. A. Tovar, C. J. Essenburg, E. Wolfrum, I. Beddows, K. Williams, R. Sheridan, J. Schipper, M. Adams, M. Arumugam, T. Vander Woude, S. Gurunathan, J. M. Field, J. Wulfkuhle, , M. Steensma

This study shows p53 loss in NF1-related MPNSTs leads to MET instability, kinome reprogramming, and therapy resistance through altered signaling and lineage plasticity.

bioRxiv · Jan 18, 2023Cancer Biology