BiochemistrybioRxiv
Cyclic peptides can engage a single binding pocket through multiple, entirely divergent modes
K. Patel, L. J. Walport, J. L. Walshe…·J. P. Mackay
The paper identifies high-affinity, specific cyclic peptide inhibitors of BET bromodomains using RaPID screening, revealing diverse binding modes and structures.
DOI 10.1073/pnas.2003086117