Author

L. J. Walport

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Assay:protein structure· 2 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1 Approach:statistical model· 1

Frequent Co-Authors

H. Suga· 3 shared K. Patel· 3 shared R. J. Payne· 3 shared T. Passioura· 3 shared A. Norman· 2 shared J. P. Mackay· 2 shared P. Solomon· 2 shared A. P. G. Silva· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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3 shared papersBiochemistry

H. Suga

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3 papers

Recent·Most cited

BiochemistrybioRxivMay 17, 2023

mRNA display reveals a class of high-affinity bromodomain-binding motifs that are not found in the human proteome

J. K. Low, K. Patel, P. Solomon…·J. Mackay

The paper uses mRNA display to identify high-affinity bromodomain-binding motifs not present in the human proteome, revealing novel binding modes and suggesting evolutionary pressure against strong binders.

DOI 10.1016/j.jbc.2023.105482

proteomicsexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivDec 25, 2022

Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins

C. Franck, K. Patel, L. J. Walport…·J. P. Mackay

The paper discovers and characterizes cyclic peptides that selectively bind to the C-terminal bromodomains of BET family proteins, showing high potency and paralogue-specificity.

DOI 10.1016/j.str.2023.05.009

protein structureexperimental assay

𝕏 PostBluesky

BiochemistrybioRxivNov 21, 2019

Cyclic peptides can engage a single binding pocket through multiple, entirely divergent modes

K. Patel, L. J. Walport, J. L. Walshe…·J. P. Mackay

The paper identifies high-affinity, specific cyclic peptide inhibitors of BET bromodomains using RaPID screening, revealing diverse binding modes and structures.

DOI 10.1073/pnas.2003086117

protein structureexperimental assay

𝕏 PostBluesky