K. Patel

Discovery of RNA-Protein Molecular Clamps Using Proteome-Wide Stability Assays

The paper develops a method to discover RNA-protein-small molecule complexes using proteome-wide stability assays and applies it to identify novel DDX helicase targets of rocaglates.

ORF48 is required for optimal lytic replication of Kaposis Sarcoma-Associated Herpesvirus

This study shows ORF48 is essential for KSHV lytic replication by inhibiting the cGAS-STING pathway and blocking innate immune signaling.

Coordinate regulation of Activin and Bone Morphogenetic Protein signaling by a lysosomal trafficking switch

The paper shows that ActA forms non-signaling complexes with ACVR1 that are trafficked to lysosomes and degraded, unlike Activin B, AC, and AB which remain on the surface.

Sporadic phage defense in epidemic Vibrio cholerae mediated by the toxin-antitoxin system DarTG is countered by a phage-encoded antitoxin mimic

The paper identifies the DarTG toxin-antitoxin system in Vibrio cholerae that inhibits the lytic phage ICP1, and shows ICP1 counters this with an antitoxin mimic, revealing co-evolutionary dynamics between the bacterium and its phage.

A proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastoma

This study identifies DLK1 as a potential immunotherapeutic target in neuroblastoma through integrative proteomic, transcriptomic, and epigenomic analysis.

An immunohistochemical atlas of necroptotic pathway expression

The paper develops automated immunohistochemistry protocols to detect necroptotic pathway proteins in mouse and human tissues, revealing heterogeneity and disease-related changes in expression.

Nucleo-cytoplasmic environment modulates spatio-temporal p53 phase separation

This study shows that p53 phase separation and condensate formation are modulated by the nucleo-cytoplasmic environment and cancer-associated mutations affect condensate stability and DNA binding.

Mast-Cell Expressed Membrane Protein-1 (MCEMP1) is expressed in classical monocytes and alveolar macrophages in Idiopathic Pulmonary Fibrosis and regulates cell chemotaxis, adhesion, and migration in a TGFβ dependent manner.

This study identifies MCEMP1 as highly expressed in monocytes and macrophages in IPF, regulated by TGFβ and involved in chemotaxis, adhesion, and migration through RHO GTPase modulation.

miR-324 mediates bone homeostasis through the regulation of osteoblast and osteoclast differentiation and activity

This study shows miR-324 regulates bone homeostasis by controlling osteoblast and osteoclast activity, with its deletion causing increased bone mass and cartilage damage in OA and aging.

Groundwater redox dynamics across the terrestrial-aquatic interface of Lake Erie coastal ecosystems

The paper examines groundwater redox dynamics in Lake Erie coastal areas, finding oxidizing conditions during high water and reducing during low water, with hysteresis effects and implications for biogeochemical models.

mRNA display reveals a class of high-affinity bromodomain-binding motifs that are not found in the human proteome

The paper uses mRNA display to identify high-affinity bromodomain-binding motifs not present in the human proteome, revealing novel binding modes and suggesting evolutionary pressure against strong binders.

Ischemia/Reperfusion Injury and Oxidative Stress Impair Cardiac Desmin Proteostasis

This study investigates how oxidative stress and reperfusion injury affect desmin proteostasis, identifying mechanisms to reduce toxic desmin aggregates and improve cardiac function.

The structure of the neurotoxin palytoxin determined by MicroED

This study determines the structure of palytoxin using MicroED, revealing its hairpin fold and binding to Na,K-ATPase, providing insights into its mechanism and potential therapeutic applications.

A novel human iPSC model of COL4A1/A2 small vessel disease unveils a key pathogenic role of matrix metalloproteinases in extracellular matrix abnormalities

This paper develops a human iPSC model of COL4A1/A2 small vessel disease, showing that MMP inhibition rescues ECM abnormalities and mural cell defects.

Discovery and characterization of cyclic peptides selective for the C-terminal bromodomains of BET family proteins

The paper discovers and characterizes cyclic peptides that selectively bind to the C-terminal bromodomains of BET family proteins, showing high potency and paralogue-specificity.

MLKL deficiency protects against low-grade, sterile inflammation in aged mice

This study shows that MLKL deficiency reduces age-related sterile inflammation in mice by preserving lymphocyte levels and reducing inflammatory infiltrates in tissues.

Salivary exosomal miR-1307-5p predicts disease aggressiveness and poor prognosis in oral squamous cell carcinoma patients

This study identifies miR-1307-5p in salivary exosomes as a prognostic marker for poor survival and disease aggressiveness in oral squamous cell carcinoma.

A novel 3-miRNA network regulates tumour progression in oral squamous cell carcinoma

This study identifies a 3-miRNA signature in salivary exosomes that predicts OSCC progression and reveals its role in regulating EMT and tumor cell behavior.

Identification and characterization of the T cell receptor (TCR) repertoire of the Cynomolgus macaque (Macaca Fascicularis)

The paper characterizes the T cell receptor repertoire in Cynomolgus macaques using single-cell RNA sequencing and identifies similarities with human and Rhesus macaque TCR repertoires.

Presence of sodium taurocholate co-transporting polypeptide and Hepatitis B replication marker on placenta: Another home for the virus

The paper investigates NTCP and HBV replication markers in placental cells, finding NTCP expression and viral markers suggesting placental susceptibility to HBV and potential replication.

Liquid condensate is a common state of proteins and polypeptides at the regime of high intermolecular interactions

The paper demonstrates that proteins and polypeptides can form liquid condensates under high intermolecular interaction conditions, showing that LLPS is a common state across diverse molecular structures.

Fibroblast-expressed LRRC15 suppresses SARS-CoV-2 infection and controls antiviral and antifibrotic transcriptional programs.

This study identifies LRRC15 as a host factor that suppresses SARS-CoV-2 infection and regulates antiviral and antifibrotic transcriptional programs in fibroblasts.

Spatiotemporal solidification of α-synuclein inside the liquid droplets

This study investigates the spatiotemporal solidification of α-synuclein within liquid droplets, showing how solid-like cores form and propagate during droplet aging and fusion.

Phylogenetic diversity and activity screening of cultivable actinobacteria isolated from marine sponges and associated environments from the western coast of India

The paper studies actinobacteria from marine sponges and associated environments, identifying new species and reporting predatory behavior and antibacterial activity.

Fanconi Anemia Pathway Deficiency Drives Copy Number Variation in Squamous Cell Carcinomas

This paper shows that FA pathway deficiency in squamous cell carcinomas leads to high structural variant rates and copy number alterations, linking genomic instability to tumor progression.

Discovery of Cyclic Peptide Ligands to the SARS-CoV-2 Spike Protein using mRNA Display

The paper identifies cyclic peptide ligands to the SARS-CoV-2 spike protein RBD using mRNA display, finding six high-affinity molecules with nanomolar dissociation constants.

Genomic evidence for inbreeding depression and purging of deleterious genetic variation in Indian tigers

This study uses whole-genome sequencing of Indian tigers to show that small-isolated populations have higher inbreeding depression and purging of deleterious alleles compared to larger, connected populations.

PI3Kγ inhibition suppresses microglia/TAM accumulation in glioblastoma microenvironment to promote exceptional temozolomide response

The paper identifies PI3Kγ as a driver of microglia/macrophage accumulation in glioblastoma, showing its inhibition enhances temozolomide response in preclinical models.

Tissue specific requirements for ECSIT in mitochondrial complex I assembly

The paper identifies a mutation in ECSIT that specifically disrupts mitochondrial complex I assembly in heart tissue, causing hypertrophic cardiomyopathy without affecting other tissues.

Amyloid fibril-based hydrogels for high-throughput tumor spheroid modeling

This paper develops amyloid fibril-based hydrogels for 3D tumor spheroid modeling, showing enhanced drug resistance and cancer biomarker expression compared to 2D cultures.