BiochemistrybioRxiv
Structure of the human clamp loader bound to the sliding clamp: a further twist on AAA+ mechanism
C. Gaubitz, X. Liu, J. Magrino…·B. A. Kelch
This paper reports the cryo-EM structure of human RFC bound to PCNA, revealing an autoinhibited conformation and a novel regulatory mechanism for AAA+ ATPases.