Genetic Predisposition to Neuroblastoma Results from a Regulatory Polymorphism that Promotes the Adrenergic Cell State
N. Weichert-Leahey, H. Shi, T. Tao, D. Oldridge, A. Durbin, B. Abraham, M. Zimmerman, S. Zhu, A. Wood, D. Reyon, J. K. Joung, R. Young, S. J. Diskin, J. Maris, A. T. Look
The paper identifies a regulatory polymorphism in LMO1 that reduces neuroblastoma risk by preventing the adrenergic cell state in zebrafish and humans.
bioRxiv · Feb 28, 2023Cancer Biology