Author

M. Zimmerman

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Cancer Biology· 1 Ecology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:drug response / drug discovery· 5 Research Focus:host-pathogen & immune response· 3 Research Focus:ecology & biodiversity· 2 Organism:human· 2 Organism:mouse· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1

Frequent Co-Authors

V. A. Dartois· 4 shared T. Dick· 3 shared V. Dartois· 3 shared D. A. Negatu· 2 shared M. Gengenbacher· 2 shared R. Russo· 2 shared R. Shrestha· 2 shared X. Wang· 2 shared

Activity by Year

2019-2023 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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4 shared papersMicrobiology

V. A. Dartois

Mutual co-authors in cluster

Author profile →

11 papers

Recent·Most cited

Development of an Engineered Mycobacterium tuberculosis Strain for a Safe and Effective Tuberculosis Human Challenge Model

X. Wang, H. Su, J. B. Wallach, J. C. Wagner, B. J. Braunecker, M. Gardner, K. M. Guinn, T. Klevorn, K. Lin, Y. J. Liu, Y. Liu, D. Mugahid, M. Rodgers, J. Sixsmith, S. Wakabayashi, , D. Schnappinger

This paper develops an engineered Mycobacterium tuberculosis strain with kill switches for a safe TB human challenge model, showing rapid clearance and low escape rates.

bioRxiv · Nov 19, 2023 · PreprintMicrobiology

Genetic Predisposition to Neuroblastoma Results from a Regulatory Polymorphism that Promotes the Adrenergic Cell State

N. Weichert-Leahey, H. Shi, T. Tao, D. Oldridge, A. Durbin, B. Abraham, M. Zimmerman, S. Zhu, A. Wood, D. Reyon, J. K. Joung, R. Young, S. J. Diskin, J. Maris, A. T. Look

The paper identifies a regulatory polymorphism in LMO1 that reduces neuroblastoma risk by preventing the adrenergic cell state in zebrafish and humans.

bioRxiv · Feb 28, 2023Cancer Biology

Macrophage internalization creates a multidrug-tolerant fungal persister population, providing a permissive reservoir for the emergence of drug resistance

A. Arastehfar, F. Daneshnia, N. Cabrera, S. Penalva-Lopez, J. Sarathy, M. Zimmerman, E. Shor, D. Perlin

This study shows that macrophage internalization creates drug-tolerant C. glabrata persisters, which can give rise to drug-resistant mutants, and that amphotericin B can kill these persisters.

bioRxiv · Oct 21, 2022 · PreprintMicrobiology

Mycobacterium tuberculosis DprE1 inhibitor OPC-167832 is active against Mycobacterium abscessus in vitro

J. P. Sarathy, M. Zimmerman, M. Gengenbacher, V. A. Dartois, T. Dick

OPC-167832, a DprE1 inhibitor active against Mycobacterium tuberculosis, shows in vitro activity against Mycobacterium abscessus but lacks efficacy in a mouse model due to moderate potency.

bioRxiv · Sep 14, 2022Microbiology

Development of amidase-dependent pyrazinoic acid prodrugs with activity against pyrazinamide resistant Mycobacterium tuberculosis

C. Levine, R. Jadhav, P. Yan, K. Tsotetsi, X. Wang, D. Awasthi, C. Grady, A. Shelke, S. S. Daher, T. Richmann, R. Shrestha, P. Sukheja, J. Patel, P. R. Barnett, R. J. Dikdan, , P. Kumar

This paper develops amidase-dependent pyrazinoic acid prodrugs that bypass PncA activation, showing efficacy against PZA-resistant Mtb.

bioRxiv · Jul 5, 2022 · PreprintMicrobiology

Strongly bactericidal all-oral β-lactam combinations for the treatment of Mycobacterium abscessus lung disease

D. A. Negatu, M. Zimmerman, V. A. Dartois, T. Dick

The paper evaluates oral β-lactam combinations with avibactam against Mycobacterium abscessus and identifies synergistic bactericidal effects.

bioRxiv · Jun 7, 2022Microbiology

Activity of Tricyclic Pyrrolopyrimidine Gyrase B Inhibitor against Mycobacterium abscessus

A. Madani, D. A. Negatu, A. E. Marrouni, R. Miller, C. Boyce, N. Murgolo, C. J. Bungard, M. Zimmerman, V. A. Dartois, M. Gengenbacher, D. B. Olsen, T. Dick

This study evaluates the activity of TPP8, a tricyclic pyrrolopyrimidine gyrase B inhibitor, against Mycobacterium abscessus in vitro, ex vivo, and in vivo.

bioRxiv · May 16, 2022Microbiology

A novel oral GyrB/ParE dual binding inhibitor effective against multidrug resistant Neisseria gonorrhoeae and other high-threat pathogens

S. Park, R. Russo, L. Westfall, R. Shrestha, M. Zimmerman, V. A. Dartois, N. Kurepina, B. Kreiswith, E. Singleton, S.-G. LI, N. Mittal, Y.-M. Ahn, j. Bilotta, K. L. Connolly, A. E. Jerse, , D. S. Perlin

The paper describes a novel oral inhibitor, JSF-2659, effective against multidrug-resistant Neisseria gonorrhoeae and other high-threat pathogens, with low potential for resistance development.

bioRxiv · Mar 23, 2022Microbiology

Temporal instability of lake charr phenotypes: synchronicity of growth rates and morphology linked to environmental variables?

L. Chavarie, S. Voelker, M. Hansen, C. Bronte, A. Muir, M. Zimmerman, c. Krueger

The paper examines phenotypic variation in lake charr ecotypes over time, finding a synchronized shift in morphology and growth rates linked to environmental changes like cloud cover.

bioRxiv · Aug 13, 2020Evolutionary Biology

Malacological survey in a bottle of water: A comparative study between manual sampling and environmental DNA metabarcoding approaches

S. Mulero, E. Toulza, A. Loisier, M. Zimmerman, J.-F. Allienne, J. Foata, Y. Quilichini, J.-P. Pointier, O. Rey, J. Boissier

The paper compares manual sampling and eDNA metabarcoding for freshwater snail detection, finding high species agreement and improved detection efficiency with eDNA.

bioRxiv · May 21, 2020Ecology

Fatty acid oxidation impairs macrophage effector functions that control Mycobacterium tuberculosis

P. Chandra, L. He, M. Zimmerman, G. Yang, S. Koster, M. Ouimet, H. Wang, K. J. Moore, V. Dartois, J. D. Schilling, J. A. Philips

This study shows that blocking fatty acid oxidation in macrophages enhances their ability to control Mycobacterium tuberculosis infection by boosting reactive oxygen species and xenophagy.

bioRxiv · Oct 10, 2019 · PreprintMicrobiology