W. Lim

Break-up and Recovery of Harmony between Direct and Indirect Pathways in The Basal Ganglia; Huntington's Disease and Treatment

This paper models the disruption and recovery of harmony between direct and indirect pathways in the basal ganglia in Huntington's disease using computational analysis of pathway strength ratios.

Enhanced fungal specificity and in vivo therapeutic efficacy of a C-22 modified FK520 analog against C. neoformans

This paper identifies a modified FK520 analog, JH-FK-08, with reduced immunosuppression and improved antifungal efficacy against C. neoformans in vivo.

Effect of Adult-Born Immature Granule Cells on Pattern Separation in The Hippocampal Dentate Gyrus

This paper develops a spiking neural network model of the hippocampal dentate gyrus to study how immature granule cells affect pattern separation through their excitability and connectivity properties.

Iron regulatory pathways differentially expressed during Madurella mycetomatis grain development in Galleria mellonella

This study identifies iron regulatory pathways involved in Madurella mycetomatis grain formation in Galleria mellonella using time-course transcriptomic profiling.

Exploration of Mechanisms of Drug Resistance in a Microfluidic Device and Patient Tissues

This study uses a microfluidic device to induce drug resistance in TNBC cells and identifies the NUPR1/HDAC11 axis as a key factor in chemoresistance, correlating high Nupr1 expression with poor clinical outcomes.

Herd immunity on chip: recapitulating virus transmission in human society

This paper presents an experimental microfluidic model to simulate herd immunity for a human coronavirus by varying cell proportions and observing transmission dynamics.

The interplay of supercoiling and thymine dimers inDNA

This study investigates how thymine dimers affect DNA supercoiling and repair mechanisms through molecular dynamics simulations.

Population and Individual Firing Behaviors in Sparsely Synchronized Rhythms in The Hippocampal Dentate Gyrus

The paper studies population and individual firing behaviors in sparsely synchronized rhythms in the hippocampal dentate gyrus, showing how winner-take-all competition leads to sparse activation and distinct firing patterns among neurons.

The development of a novel diagnostic PCR for Madurella mycetomatis using a comparative genome approach

The paper develops a novel PCR diagnostic for Madurella mycetomatis using a comparative genome approach to avoid cross-reactivity with related species.

Addressing the Most Neglected Diseases through an Open Research Model: the Discovery of Fenarimols as Novel Drug Candidates for Eumycetoma

This paper identifies new drug candidates for eumycetoma by screening 800 compounds and testing their in vitro and in vivo activity against Madurella mycetomatis, using an open-source approach to accelerate drug discovery.