J. P. Mesirov

The paper investigates SHH medulloblastoma heterogeneity by analyzing single-nucleus RNA-seq data and linking findings to developmental origins and molecular subtypes.

This study shows that lymphatic-preserving treatment sequences enhance cDC1-dependent antitumor immunity in HNSCC by avoiding lymphablation, which compromises ICI response.

This study identifies ecDNA in 18% of medulloblastoma patients, linking it to higher relapse and mortality rates and suggesting enhancer rewiring as an oncogenic mechanism.

The paper identifies germline variants associated with the tumor immune microenvironment, linking them to cancer risk and immunotherapy response.

The paper characterizes the step-wise acquisition of carboplatin resistance in ovarian cancer using single-cell gene expression analysis and identifies distinct transcriptional patterns associated with resistance.