A Cell Cycle-Dependent Ferroptosis Sensitivity Switch Governed by EMP2
J. Rodencal, N. Kim, V. Li, A. He, M. Lange, J. He, A. Tarangelo, Z. T. Schafer, J. Olzmann, J. Sage, J. Z. Long, S. J. Dixon
The paper shows cell cycle arrest increases sensitivity to GPX4 inhibitor-induced ferroptosis via elevated oxidizable phospholipids and reduced EMP2 expression.
bioRxiv · Jul 19, 2023 · PreprintCancer Biology