Author

A. He

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 5 Immunology· 3 Biochemistry· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Organism:human· 6 Research Focus:cancer & tumor microenvironment· 5 Assay:bulk RNA-seq· 3 Research Focus:drug response / drug discovery· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2

Frequent Co-Authors

J. Sage· 3 shared H. Zhang· 2 shared Y. He· 2 shared A. Banuelos· 1 shared A. Barkal· 1 shared A. Berndt· 1 shared A. Delaidelli· 1 shared A. Rashid· 1 shared

Activity by Year

2016-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 9 mutual co-author links

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3 shared papersCancer Biology

J. Sage

Mutual co-authors in cluster

Author profile →

10 papers

Recent·Most cited

Development of pre-clinical murine models for fibrolamellar hepatocellular carcinoma

A. He, G. L. Coles, G. H. Hartmann, J. Arand, V. Le, B. Mauch, L. Xu, T. Nguyen, F. K. Hazard, J. Sage

This study develops a novel transgenic mouse model of fibrolamellar hepatocellular carcinoma (FLC) and highlights challenges in establishing ex vivo cell models from FLC tumors.

bioRxiv · Dec 6, 2023 · PreprintCancer Biology

A Cell Cycle-Dependent Ferroptosis Sensitivity Switch Governed by EMP2

J. Rodencal, N. Kim, V. Li, A. He, M. Lange, J. He, A. Tarangelo, Z. T. Schafer, J. Olzmann, J. Sage, J. Z. Long, S. J. Dixon

The paper shows cell cycle arrest increases sensitivity to GPX4 inhibitor-induced ferroptosis via elevated oxidizable phospholipids and reduced EMP2 expression.

bioRxiv · Jul 19, 2023 · PreprintCancer Biology

VHL Mutation Drives Human Clear Cell Renal Cell Carcinoma Progression Through PI3K/AKT-Dependent Cholesteryl Ester Accumulation

S. Zhang, T. Fang, Y. He, W. Feng, Z. Yu, Y. Zheng, C. Zhang, S. Hu, Z. Liu, J. Liu, J. Yu, H. Zhang, A. He, Y. Gong, Z. He, , S. Yue

This study identifies VHL mutation as a driver of CE accumulation in ccRCC through the PI3K/AKT pathway, showing that inhibiting cholesterol esterification suppresses tumor aggressiveness.

bioRxiv · Jan 2, 2023Cancer Biology

Novel low-avidity glypican-3 specific CARTs resist exhaustion and mediate durable antitumor effects against hepatocellular carcinoma

L. Caraballo-Galva, M. Hussein, X. Jiang, H. Zhang, R. Mao, P. Brody, X. Chi, Y. Peng, A. He, M. Kehinge-Ige, R. Sadek, H. Shi, X. Qiu, Y. He

bioRxiv · Jul 9, 2021Immunology

INPP4B drives lysosome biogenesis to restrict leukemic stem cell differentiation and promote leukemogenesis

J. F. Woolley, K. Chen, G. T. Saffi, G. E. Genc, D. K. C. Lee, I. Dzneladze, R. He, J. T.-S. Chow, M. M. Gabra, M. H. Son, C. M. P. Melo, C. A. Newell, A. He, E. M. Schoof, S. Z. Xie, , L. Salmena

This study identifies INPP4B's role in promoting leukemic stem cell (LSC) survival by enhancing lysosome biogenesis, leading to poor AML prognosis and suggesting therapeutic targets.

bioRxiv · Mar 25, 2021 · PreprintCancer Biology

Anti-GD2 antibody disrupts GD2:Siglec-7 interactions and synergizes with CD47 blockade to mediate tumor eradication

J. Theruvath, M. Menard, B. A. Smith, M. H. Linde, G. Coles, W. Wu, L. Kiru, A. Delaidelli, J. L. Silberstein, A. Banuelos, S. Dhingra, E. Sotillo, S. Heitzeneder, A. Tousley, J. Lattin, , R. G. Majzner

This study shows that combining anti-GD2 and anti-CD47 antibodies enhances anti-tumor responses by recruiting macrophages and disrupting the GD2:Siglec-7 interaction in GD2+ cancers.

bioRxiv · Mar 19, 2021 · PreprintImmunology

Selective inhibition reveals the regulatory function of DYRK2 in protein synthesis and calcium entry

X. Lei, T. Wei, J. Wang, R. Liang, W. Chen, A. He, Y. Du, W. Zhou, Z. Zhang, M. Ma, J. Lu, X. Guo, X. Chen, R. Tian, J. Xiao

This study develops a selective DYRK2 inhibitor, C17, and identifies novel targets like 4E-BP1 and STIM1, revealing DYRK2's role in protein synthesis and calcium entry.

bioRxiv · Feb 12, 2021Biochemistry

Recombinant SARS-CoV-2 spike S1-Fc fusion protein induced high levels of neutralizing responses in nonhuman primates

W. Ren, H. Sun, G. F. Gao, J. Chen, S. Sun, R. Zhao, G. Gao, Y. Hu, G. Zhao, Y. Chen, X. Jin, F. Fang, J. Chen, Q. Wang, S. Gong, , L. Sun

This study shows that a recombinant SARS-CoV-2 S1-Fc fusion protein induces strong neutralizing antibodies in nonhuman primates and can be produced at scale for vaccine development.

bioRxiv · Apr 21, 2020Immunology

JQ1 reduces Epstein-Barr virus-associated lymphoproliferative disease in mice without sustained oncogene repression

A. He, J. L. Miranda

This study tests JQ1, a BET inhibitor, in a mouse model of EBV-associated lymphoproliferative disease and finds it reduces disease without sustained oncogene repression.

bioRxiv · Jun 19, 2017Cancer Biology

Benzoate and Salicylate Tolerant Strains Lose Antibiotic Resistance during Laboratory Evolution of Escherichia coli K-12

K. E. Creamer, F. S. Ditmars, P. J. Basting, K. S. Kunka, I. N. Hamdallah, S. P. Bush, Z. Scott, A. He, S. R. Penix, A. S. Gonzales, E. K. Eder, D. Camperchioli, A. Berndt, M. W. Clark, K. A. Rouhier, J. L. Slonczewski

This study shows that laboratory evolution of E. coli K-12 under benzoate or salicylate stress leads to loss of antibiotic resistance and MDR gene regulators.

bioRxiv · Sep 28, 2016Microbiology