J. Z. Long

This study identifies Lac-Phe as a mediator of metformin's anti-obesity effects through experiments in mice and human cohorts.

The paper shows cell cycle arrest increases sensitivity to GPX4 inhibitor-induced ferroptosis via elevated oxidizable phospholipids and reduced EMP2 expression.

The paper identifies a new class of secreted mammalian peptides, capped peptides, which may regulate cell-cell communication through post-translational modifications.

The paper identifies CYP4F2 as a human-specific genetic determinant of plasma N-acyl amino acid levels and shows its role in metabolic diversification.

The paper identifies a plasma globulin in poison frogs that binds and regulates alkaloid bioavailability, revealing a novel serpin-based mechanism for small molecule transport.

The paper shows that p53 inhibition of nucleotide metabolism reduces ferroptosis by preserving glutathione levels through RNR suppression.

This study identifies serine hydrolases in Toxoplasma gondii that hydrolyze lipid esters, showing their role in lipid metabolism and potential as therapeutic targets.

The paper introduces a method to profile cell-type-specific secretomes in vivo and identifies novel secreted proteins and dynamic changes in hepatocyte secretomes.

The study identifies essential α/β serine hydrolases in P. falciparum as targets of the antimalarial Salinipostin A, which disrupt lipid metabolism and inhibit parasite growth.