Actin filaments couple the protrusive tips to the nucleus through the I-BAR domain protein IRSp53 for migration of elongated cells on 1D fibers
A. Mukherjee, J. Ron, H. T. Hu, T. Nishimura, K. Hanawa-Suetsugu, B. Behkam, N. Gov, S. Suetsugu, A. Nain
This study shows that IRSp53 couples actin filaments to the nucleus via membrane curvature during 3D cell migration on 1D fibers, affecting protrusion and contractility.
bioRxiv · May 20, 2022 · PreprintCell Biology