S. Suetsugu

The paper extends a physical model of membrane protrusions driven by curved active proteins to explore the formation of different protrusive structures like lamellipodia and filopodia.

This study shows that IRSp53 couples actin filaments to the nucleus via membrane curvature during 3D cell migration on 1D fibers, affecting protrusion and contractility.

This study shows that FCHO2-generated membrane curvature activates Nedd4L by relieving its autoinhibition, facilitating ENaC ubiquitination and endocytosis.

This study uses a generative adversarial network to translate actin filament images into protein localization images, showing high similarity for actin-related proteins but lower for microtubules.

This study shows IRSp53 promotes tumor cell proliferation through microvesicle secretion, as evidenced by reduced secretion and phosphorylation in knockout cells and increased survival in IRSp53-deficient mice.

This study shows that PACSIN2-mediated membrane tubulation and caveolae internalization are regulated by cholesterol levels in the plasma membrane.