BiochemistrybioRxivPreprint
Mutational and biophysical robustness in a pre-stabilized monobody
P. G. Chandler, L. L. Tan, B. T. Porebski…·A. M. Buckle
This paper grafts binding loops from an Adnectin onto a pre-stabilized FN3Con scaffold to create a stable monobody that binds VEGFR2 with high affinity and long-term stability.
DOI 10.1101/2020.12.14.422768