Author

P. G. Chandler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2

Signature Assays, Organisms & Methods

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Research Focus:protein folding & dynamics· 2 Approach:biophysical modeling· 1 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:protein sequence· 1

Frequent Co-Authors

A. M. Buckle· 2 shared D. E. Hoke· 2 shared B. T. Porebski· 1 shared B. T. Riley· 1 shared C. J. Jackson· 1 shared D. E. Williams· 1 shared J. P. Banga· 1 shared J. S. Green· 1 shared

Activity by Year

2019-2020 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersBiochemistry

A. M. Buckle

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2 papers

Recent·Most cited

BiochemistrybioRxivPreprintDec 14, 2020

Mutational and biophysical robustness in a pre-stabilized monobody

P. G. Chandler, L. L. Tan, B. T. Porebski…·A. M. Buckle

This paper grafts binding loops from an Adnectin onto a pre-stabilized FN3Con scaffold to create a stable monobody that binds VEGFR2 with high affinity and long-term stability.

DOI 10.1101/2020.12.14.422768

protein structureprotein sequence

𝕏 PostBluesky

BiochemistrybioRxivDec 15, 2019

Structural studies of thyroid peroxidase show the monomer interacting with autoantibodies in thyroid autoimmune disease

D. E. Williams, S. N. Le, D. E. Hoke…·A. M. Buckle

This study characterizes the structural and biophysical properties of thyroid peroxidase constructs and shows how autoantibodies bind the monomeric form, revealing conformational changes in the epitope.

DOI 10.1210/endocr/bqaa016

humanstructural biology

𝕏 PostBluesky