J. S. Klassen

This study investigates how N343 glycosylation affects the structure and co-receptor binding of the SARS-CoV-2 S RBD across variants of concern using molecular dynamics simulations.

This study shows that specific sulfate modifications on Siglec ligands, mediated by CHSTs, can enhance or reduce Siglec binding, with implications for cancer immune evasion.

This study shows SARS-CoV-2 RBD binds sialylated glycans, particularly gangliosides, and that reducing cell surface sialic acid decreases viral entry.

This paper introduces a versatile Siglec-Fc scaffold for detecting glycan ligands, revealing new patterns on healthy and cancerous cells and clarifying ligand specificities, including for CD33.