Author

C. A. Fogarty

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 7

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Research Focus:protein folding & dynamics· 6 Approach:deep learning· 3 Organism:human· 3 Assay:structural biology· 3 Approach:biophysical modeling· 2 Approach:mechanistic / dynamical model· 2 Assay:protein structure· 2 Organism:virus· 2

Frequent Co-Authors

E. Fadda· 7 shared A. M. Harbison· 6 shared A. Satheesan· 2 shared C. M. Ives· 2 shared A. C. Dommer· 1 shared A. Meller· 1 shared A. R. Dugdale· 1 shared B. C. Taylor· 1 shared

Activity by Year

2020-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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7 shared papersBiophysics

E. Fadda

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Author profile →

7 papers

Recent·Most cited

Restoring Protein Glycosylation with GlycoShape

C. M. Ives, O. Singh, S. D'Andrea, C. A. Fogarty, A. M. Harbison, A. Satheesan, B. Tropea, E. Fadda

The paper introduces GlycoShape, an open-access database and tool to restore glycosylation to protein structures using molecular dynamics simulations and public structural data.

Nature Methods · Oct 14, 2024Peer-reviewedBiophysics

GotGlycans: Role of N343 Glycosylation on the SARS-CoV-2 S RBD Structure and Co-Receptor Binding Across Variants of Concern

C. M. Ives, L. Nguyen, C. A. Fogarty, A. M. Harbison, Y. Durocher, J. S. Klassen, e. fadda

This study investigates how N343 glycosylation affects the structure and co-receptor binding of the SARS-CoV-2 S RBD across variants of concern using molecular dynamics simulations.

bioRxiv · Dec 5, 2023Biophysics

Fine-tuning the Spike: Role of the nature and topology of the glycan shield in the structure and dynamics of SARS-CoV-2 S

A. M. Harbison, C. A. Fogarty, T. K. Phung, A. Satheesan, B. L. Schulz, E. Fadda

This study uses molecular dynamics simulations to show how specific glycosylation sites on SARS-CoV-2 spike protein affect RBD stability and infectivity.

bioRxiv · Apr 1, 2021Biophysics

The oligomannose N-glycans 3D architecture and its response to the FcγRIIIa structural landscape

C. A. Fogarty, e. fadda

This study uses molecular dynamics simulations to analyze the 3D structure and conformational behavior of oligomannose N-glycans in solution and their interaction with the FcγRIIIa receptor.

bioRxiv · Jan 11, 2021Biophysics

SARS-CoV-2 Simulations Go Exascale to Capture Spike Opening and Reveal Cryptic Pockets Across the Proteome

M. I. Zimmerman, J. R. Porter, M. D. Ward, S. Singh, N. Vithani, A. Meller, U. L. Mallimadugula, C. E. Kuhn, J. H. Borowsky, R. P. Wiewiora, M. F. D. Hurley, A. M. Harbison, C. A. Fogarty, J. E. Coffland, E. Fadda, , G. R. Bowman

The paper uses exascale simulations to study SARS-CoV-2 protein dynamics, revealing cryptic epitopes and conformational changes that inform antiviral target design.

bioRxiv · Jun 27, 2020 · PreprintBiophysics

Beyond Shielding: The Roles of Glycans in SARS-CoV-2 Spike Protein

L. Casalino, Z. Gaieb, J. Goldsmith, C. K. Hjorth, A. C. Dommer, A. M. Harbison, C. A. Fogarty, E. P. Barros, B. C. Taylor, J. S. McLellan, E. Fadda, R. E. Amaro

This study reveals the structural role of glycans in modulating SARS-CoV-2 spike protein conformational dynamics and ACE2 binding through molecular simulations and experiments.

bioRxiv · Jun 11, 2020Biophysics

How and why plants and humans N-glycans are different: Insight from molecular dynamics into the "glycoblocks" architecture of complex carbohydrates

C. A. Fogarty, A. M. Harbison, A. R. Dugdale, E. Fadda

This study uses molecular dynamics to analyze N-glycan structures in plants and invertebrates, comparing them to human glycans to understand structural differences and their immunogenic effects.

bioRxiv · May 22, 2020Biophysics