Author

J. S. Morse

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Biology Disciplines

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Biochemistry· 1

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Research Focus:drug response / drug discovery· 1 Organism:E. coli· 1 Approach:experimental assay· 1

Frequent Co-Authors

C. A. Fierke· 1 shared J. T. Hampton· 1 shared K. S. Yang· 1 shared L. D. Sylvain· 1 shared P.-H. C. Chen· 1 shared S. Das· 1 shared S. Xu· 1 shared W. R. Liu· 1 shared

Activity by Year

2022-2022 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

C. A. Fierke

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1 paper

Recent·Most cited

BiochemistrybioRxivSep 14, 2022

Phage-Assisted, Active Site-Directed Ligand Evolution of a Potent and Selective Histone Deacetylase 8 Inhibitor

J. S. Morse, Y. J. Sheng, J. T. Hampton…·W. R. Liu

This paper develops PADLE, a phage-assisted method to evolve potent HDAC8 inhibitors, identifying two highly selective and potent inhibitors with sub-nanomolar Ki values.

DOI 10.1002/pro.4512

E. coliexperimental assay

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