Author

J. Schalkwijk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cell Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Organism:human· 5 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 3 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Organism:mouse· 2 Research Focus:cancer & tumor microenvironment· 1

Frequent Co-Authors

B. Campo· 2 shared D. Rodijk-Olthuis· 2 shared E. van den Bogaard· 2 shared G. Trevitt· 2 shared J. M. Bolscher· 2 shared K. J. Dechering· 2 shared K. M. Koolen· 2 shared L. E. de Vries· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersMicrobiology

B. Campo

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Advanced methodology for bacterial colonization of 3D organotypic epidermal models: a gateway to long-term host-microbe interaction and intervention studies

G. Rikken, L. Meesters, P. Jansen, D. Rodijk-Olthuis, I. van Vlijmen-Willems, H. Niehues, P. Olah, B. Homey, J. Schalkwijk, P. Zeeuwen, E. van den Bogaard

This paper introduces a method for bacterial colonization of 3D organotypic epidermal models, enabling long-term host-microbe interaction studies and antibiotic interventions.

bioRxiv · Jun 21, 2023 · PreprintMicrobiology

The aryl hydrocarbon receptor regulates epidermal differentiation through transient activation of TFAP2A

J. P. H. Smits, J. Qu, F. Pardow, N. van den Brink, D. Rodijk-Olthuis, I. Vlijmen, S. J. van Heeringen, P. Zeeuwen, J. Schalkwijk, H. Zhou, E. van den Bogaard

This study shows that AHR activates TFAP2A to regulate epidermal differentiation and barrier function in human keratinocytes.

bioRxiv · Jun 7, 2023Cell Biology

Preclinical characterization and target validation of the antimalarial pantothenamide MMV693183

L. E. de Vries, P. A. Jansen, C. Barcelo, J. Munro, J. M. Verhoef, C. F. A. Pasaje, K. Rubiano, J. Striepen, J. M. Bolscher, R. Henderson, T. Huijs, K. M. Koolen, P. K. Tumwebaze, T. Yeo, A. C. Aguiar, , K. J. Dechering

This paper characterizes MMV693183, a novel antimalarial compound targeting acetyl-CoA synthetase, showing in vitro and in vivo efficacy against Plasmodium species and transmission blocking.

bioRxiv · May 12, 2021Microbiology

The tumour microenvironment shapes dendritic cell plasticity in a human organotypic melanoma culture

S. Di Blasio, M. Tazzari, G. van Wigcheren, A. van Duffelen, I. Stefanini, M. Bloemendal, M. Gorris, A. Vasaturo, G. Bakdash, S. V. Hato, J. Schalkwijk, I. J. M. de Vries, E. H. van den Bogaard, C. G. Figdor

This study develops an organotypic melanoma culture to study TME effects on dendritic cell plasticity, finding tumour-driven conversion of cDC2s into CD14+ immunosuppressive DCs.

bioRxiv · Feb 27, 2019Immunology

Antimalarial pantothenamide metabolites target acetyl-CoA synthesis in Plasmodium falciparum

J. Schalkwijk, E. L. Allman, P. A. Jansen, L. E. de Vries, S. Jackowski, P. N. Botman, C. A. Beuckens-Schortinghuis, K. M. Koolen, J. M. Bolscher, M. W. Vos, K. Miller, S. Reeves, H. Pett, G. Trevitt, S. Wittlin, , K. J. Dechering

Pantothenamides form antimetabolites that interfere with acetyl-CoA metabolism in the human malaria parasite Plasmodium falciparum.

bioRxiv · Feb 12, 2018Pharmacology & Toxicology