Author

J. Schlezinger

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pharmacology & Toxicology· 4

Signature Assays, Organisms & Methods

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Organism:mouse· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

G. Nielsen· 2 shared T. Webster· 2 shared W. Heiger-Bernays· 2 shared A. Hussein· 1 shared E. Reed· 1 shared H. Puckett· 1 shared J. Oliver· 1 shared R. Freid· 1 shared

Activity by Year

2020-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersPharmacology & Toxicology

G. Nielsen

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4 papers

Recent·Most cited

Predicting the Effects of Per- and Polyfluoroalkyl Substance Mixtures on Peroxisome Proliferator-Activated Receptor Alpha Activity in Vitro

G. Nielsen, W. Heiger-Bernays, J. Schlezinger, T. Webster

This study evaluates modeling approaches to predict the effects of PFAS mixtures on hPPAR activity in vitro, finding that GCA provides the most accurate predictions for diverse agonist and antagonist combinations.

bioRxiv · Sep 30, 2021Pharmacology & Toxicology

A Data-Driven Transcriptional Taxonomy of Adipogenic Chemicals to Identify White and Brite Adipogens

S. Kim, E. Reed, S. Monti, J. Schlezinger

The paper develops a classification system to identify PPARγ ligands and categorize chemicals as white or brite adipogens using RNA-Seq and lipid accumulation data.

bioRxiv · Apr 29, 2021Pharmacology & Toxicology

Tributyltin Protects Against Ovariectomy-Induced Trabecular Bone Loss in C57BL/6J Mice with an Attenuated Effect in High Fat Fed Mice

R. Freid, A. Hussein, J. Schlezinger

This study shows that tributyltin (TBT) protects against ovariectomy-induced trabecular bone loss in low-fat-fed mice but not in high-fat-fed mice.

bioRxiv · Apr 28, 2021Pharmacology & Toxicology

Perfluorooctanoic acid activates multiple nuclear receptor pathways and skews expression of genes regulating cholesterol homeostasis in liver of humanized PPARα mice fed an American diet

J. Schlezinger, H. Puckett, J. Oliver, G. Nielsen, W. Heiger-Bernays, T. Webster

This study shows PFOA exposure increases liver mass and alters cholesterol-related gene expression in hPPAR mice fed an American diet.

bioRxiv · Jan 30, 2020Pharmacology & Toxicology