Author

A. Hussein

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 2 Biophysics· 1 Ecology· 1 Pathology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:protein folding & dynamics· 3 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Assay:structural biology· 2 Organism:bacteria (other)· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

D. Jones· 2 shared H. Saeed· 2 shared N. Noby· 2 shared P. Rizkallah· 2 shared A. Adegunsoye· 1 shared A. Embaby· 1 shared A. Embady· 1 shared A. Sperling· 1 shared

Activity by Year

2021-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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2 shared papersBiochemistry

D. Jones

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Energy Coupling and Stoichiometry of Zn2+/H+ Antiport by the Cation Diffusion Facilitator YiiP

A. Hussein, S. Fan, M. L. Lopez-Redondo, I. Kenney, X. Zhang, O. Beckstein, D. L. Stokes

This study investigates the structural and functional roles of Zn2+/H+ antiport in YiiP using cryo-EM, thermophoresis, and simulations, revealing a transport stoichiometry of 1 Zn2+ to 2-3 H+.

bioRxiv · Feb 23, 2023 · PreprintBiophysics

COMPARISON OF WOODY SPECIES DIVERSITY AND POPULATION STRUCTURE STATUS ACROSS DIFFERENT MANAGEMENT PRACTICE IN THE GOLA NATURAL VEGETATION, EASTER HARARGHE, OROMIA OF ETHIOPIA

A. Hussein, A. Hussein

The paper compares woody species diversity and population structure across different land use systems in Gola natural vegetation, Ethiopia, finding that protected areas have higher diversity and density than farming and grazing lands.

bioRxiv · Sep 17, 2021 · PreprintEcology

Tributyltin Protects Against Ovariectomy-Induced Trabecular Bone Loss in C57BL/6J Mice with an Attenuated Effect in High Fat Fed Mice

R. Freid, A. Hussein, J. Schlezinger

This study shows that tributyltin (TBT) protects against ovariectomy-induced trabecular bone loss in low-fat-fed mice but not in high-fat-fed mice.

bioRxiv · Apr 28, 2021Pharmacology & Toxicology

Structure and dynamics of a cold-active esterase reveals water entropy and active site accessibility as the likely drivers for cold-adaptation

N. Noby, H. Sabah Auhim, H. Worthy, S. Winter, A. Embady, H. Saeed, A. Hussein, C. Pudney, P. Rizkallah, S. A. Wells, D. Jones, C. R. Pudney

This study determines the structure of a cold-active esterase and identifies increased substrate accessibility and water entropy tolerance as the main drivers of its cold adaptation.

bioRxiv · Feb 23, 2021 · PreprintBiochemistry

Structure guided engineering of a cold active esterase expands substrate range though a stabilisation mutation that allows access to a buried water chamber

N. Noby, R. Johnson, J. Tyzack, A. Embaby, H. Saeed, A. Hussein, S. Khattab, P. Rizkallah, D. Jones

The paper engineers a cold-active esterase to expand its substrate range by stabilizing a structural mutation that allows access to a buried water chamber.

bioRxiv · Feb 23, 2021 · PreprintBiochemistry

SARS-CoV-2 infection reduces Krüppel-Like Factor 2 in human lung autopsy

T.-H. Lee, D. Wu, R. Guzy, N. Schoettler, A. Adegunsoye, J. Mueller, A. Hussein, A. Sperling, G. M. Mutlu, Y. Fang

This study shows that SARS-CoV-2 infection reduces KLF2 in human lung autopsies, linking KLF2 down-regulation to vascular dysfunction in ARDS.

bioRxiv · Jan 15, 2021 · PreprintPathology