Cell BiologybioRxivPreprint
Regulation of Epithelial HIF by Probiotic Escherichia coli
Alexander S. Dowdell, Rebecca L. Roer, Geetha Bhagavatula…·Sean P. Colgan
This study shows that probiotic E. coli stabilizes HIF in intestinal epithelial cells, promoting a pro-barrier transcriptional program through aerobic respiration, and induces tissue hypoxia in vivo.
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