Alexander S. Dowdell

This study identifies a butyrate analog, 3-chlorobutyrate, that enhances epithelial barrier formation and is protective in colitis without affecting intestinal stem cells.

This paper identifies adenosine metabolism as a mechanism that enhances antibiotic sensitivity by increasing proton motive force and cytoplasmic alkalinization in bacteria.

This study shows that probiotic E. coli stabilizes HIF in intestinal epithelial cells, promoting a pro-barrier transcriptional program through aerobic respiration, and induces tissue hypoxia in vivo.

This study shows that microbiota-dependent indole production is essential for collagen-induced arthritis development and identifies potential therapeutic targets.