Geetha Bhagavatula

This study identifies a butyrate analog, 3-chlorobutyrate, that enhances epithelial barrier formation and is protective in colitis without affecting intestinal stem cells.

This study shows that mitochondrial ATP production, induced by D-α-hydroxybutyrate, promotes T cell differentiation and function by regulating chromatin accessibility and gene expression.

This study shows that epithelial HO-1 promotes colonic tumorigenesis in chronic inflammation by increasing iron availability and oxidative stress, while protecting against acute heme toxicity.

This study shows that probiotic E. coli stabilizes HIF in intestinal epithelial cells, promoting a pro-barrier transcriptional program through aerobic respiration, and induces tissue hypoxia in vivo.