The carnitine shuttle links mitochondrial metabolism to histone acetylation and lipogenesis
L. T. Izzo, S. Trefely, C. Demetriadou, J. Drummond, T. Mizukami, N. Kuprasertkul, A. Farria, P. Nguyen, L. Reich, J. Shaffer, H. Affronti, A. Carrer, A. Andrews, B. C. Capell, N. W. Snyder, K. E. Wellen
This study identifies the carnitine shuttle and CrAT as a pathway for mitochondrial-to-cytosolic acetyl-CoA transfer, independent of ACLY, in cancer cells.
bioRxiv · Sep 24, 2022 · PreprintCell Biology