Author

H. Affronti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

K. E. Wellen· 2 shared S. Trefely· 2 shared A. Andrews· 1 shared A. Carrer· 1 shared A. Farria· 1 shared A. Singh· 1 shared B. C. Capell· 1 shared B. E. Schaffer· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersCell Biology

K. E. Wellen

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Therapeutic targeting of ACLY in T-ALL in vivo

V. da Silva-Diz, A. Singh, M. Aleksandrova, O. Kim, C. Thai, O. Lancho, P. R. Nunes, H. Affronti, X. Su, K. Wellen, D. Herranz

This study identifies ACLY as an overexpressed therapeutic target in T-ALL, showing its antileukemic effects and reciprocal relationship with MYC.

bioRxiv · Mar 27, 2023Cancer Biology

The carnitine shuttle links mitochondrial metabolism to histone acetylation and lipogenesis

L. T. Izzo, S. Trefely, C. Demetriadou, J. Drummond, T. Mizukami, N. Kuprasertkul, A. Farria, P. Nguyen, L. Reich, J. Shaffer, H. Affronti, A. Carrer, A. Andrews, B. C. Capell, N. W. Snyder, K. E. Wellen

This study identifies the carnitine shuttle and CrAT as a pathway for mitochondrial-to-cytosolic acetyl-CoA transfer, independent of ACLY, in cancer cells.

bioRxiv · Sep 24, 2022 · PreprintCell Biology

Glutamine deprivation triggers NAGK-dependent hexosamine salvage

S. L. Campbell, C. Mesaros, L. Izzo, H. Affronti, T. Tsang, M. Noji, B. E. Schaffer, K. Sun, S. Trefely, S. Kruijning, J. Blenis, I. A. Blair, K. E. Wellen

This study shows that glutamine deprivation in pancreatic ductal adenocarcinoma cells increases free GlcNAc and activates NAGK-dependent hexosamine salvage to support tumor growth.

bioRxiv · Sep 13, 2020Cancer Biology