P. Nguyen

A Novel Therapeutic Approach using CXCR3 Blockade to Treat Immune Checkpoint Inhibitor-mediated Myocarditis

This study identifies CXCR3-CXCL9/10 axis as a therapeutic target for ICI-mediated myocarditis using mouse models and human patient data.

Formation of hemiclonal reproduction and hybridogenesis in Pelophylax water frogs studied with species-specific cytogenomic probes

This study investigates the transition to asexual reproduction in water frogs through hybridogenesis, using cytogenomic probes to show DNA elimination and gametogenic modifications in F1 hybrids.

Multiple sex chromosomes of Yponomeuta ermine moths suggest a role of sexual antagonism in sex chromosome turnover in Lepidoptera

The paper identifies a multiple sex chromosome system in ermine moths and hypothesizes sexual antagonism drove sex chromosome turnover in Lepidoptera.

The carnitine shuttle links mitochondrial metabolism to histone acetylation and lipogenesis

This study identifies the carnitine shuttle and CrAT as a pathway for mitochondrial-to-cytosolic acetyl-CoA transfer, independent of ACLY, in cancer cells.

Allosteric Regulation of a Synaptic Vesicle Glutamate Transporter

The paper determines the structure of VGLUT2 with a glutamate analog bound, revealing mechanisms of substrate recognition, electrostatic interactions, and palmitoylation's role in transporter retrieval.

Sex chromosome differentiation via changes in the Y chromosome repeat landscape in African annual killifishes Nothobranchius furzeri and N. kadleci

The paper investigates sex chromosome differentiation in two killifish species by analyzing repetitive DNA landscapes, revealing shared XY systems and alternative evolutionary mechanisms.

Realtime morphological characterization and sorting of unlabeled viable cells using deep learning

COSMOS enables real-time, unlabeled cell sorting based on morphology using deep learning, achieving high enrichment of viable cells for functional analysis.

An mRNA processing pathway suppresses metastasis by governing translational control from the nucleus

The paper identifies HNRNPC and PABPC4 as regulators of alternative polyadenylation that suppress breast cancer metastasis by controlling mRNA translation.

Targeting of Cdc42 GTPase in regulatory T cells unleashes anti-tumor T cell immunity

This study shows that targeting Cdc42 in regulatory T cells promotes anti-tumor immunity without causing autoimmunity by inducing Treg plasticity and altering pH through carbonic anhydrase I.

Brain Injury Localization in Electromagnetic Imaging using Symmetric Crossing Lines Method

This paper introduces a novel method for localizing brain injuries using symmetric antenna signal intersections and demonstrates an accuracy of 0.85 Dice similarity coefficient.

iPSC modeling shows uncompensated mitochondrial mediated oxidative stress underlies early heart failure in hypoplastic left heart syndrome

This study uses iPSC-derived cardiomyocytes to show that mitochondrial oxidative stress and ER stress underlie early heart failure in HLHS patients.

A human ex vivo dengue virus neutralization assay identifies priority antibodies and epitopes for vaccines and therapeutics.

This study develops an ex vivo dengue virus neutralization assay using mosquitoes to identify potent human monoclonal antibodies and their epitopes for vaccine and therapeutic development.

A metabolic switch from OXPHOS to glycolysis is essential for cardiomyocyte proliferation in the regenerating heart

This study identifies a metabolic switch from OXPHOS to glycolysis in regenerating zebrafish hearts, showing it is essential for cardiomyocyte proliferation and heart regeneration.