Author

J. Shirian

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

E. S. Radisky· 2 shared I. Cohen· 2 shared J. M. Shifman· 2 shared N. Papo· 2 shared M. Heyne· 1 shared T. Sapir· 1 shared V. Arkadash· 1 shared Y. Peleg· 1 shared

Activity by Year

2017-2020 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 24 mutual co-author links

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2 shared papersBiophysics

E. S. Radisky

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2 papers

Recent·Most cited

BiophysicsbioRxivOct 14, 2020

Climbing up and down binding landscapes: a high-throughput study of mutational effects in homologous protein-protein complexes

M. Heyne, J. Shirian, I. Cohen…·J. M. Shifman

This study quantifies mutational effects on binding affinity in three homologous protease-inhibitor complexes, revealing distinct binding landscapes and epistasis patterns.

DOI 10.1021/jacs.1c08707

proteomicsdeep learning

𝕏 PostBluesky

BiophysicsbioRxivDec 31, 2017

Converting a broad matrix metalloproteinase family inhibitor into a specific inhibitor of MMP-9 and MMP-14

J. Shirian, V. Arkadash, I. Cohen…·J. M. Shifman

The paper engineers a specific inhibitor for MMP-9 and MMP-14 from a broad MMP inhibitor using computational design and yeast surface display, showing enhanced specificity and structural insights.

DOI 10.1002/1873-3468.13016

experimental assaydrug response / drug discovery

𝕏 PostBluesky