ImmunologybioRxiv
Post-transcriptional regulatory feedback encodes JAK-STAT signal memory of interferon stimulation
E. Kalliara, M. Kardynska, J. Bagnall…·P. Paszek
The paper shows that interferon stimulation induces long-term STAT1 desensitization through post-transcriptional feedback, enabling cells to remember past stimulation and adjust future responses.
DOI 10.3389/fimmu.2022.947213