P. Paszek

High-Dimensional Imaging of Vestibular Schwannoma Reveals Distinctive Immunological Networks Across Histomorphic Niches in NF2-related Schwannomatosis

This study uses imaging mass cytometry to analyze spatial immunological differences in vestibular schwannomas from NF2 SWN patients, revealing niche-dependent T-cell regulation.

Working together to control mutation: how collective peroxide detoxification determines microbial mutation rate plasticity

This study identifies hydrogen peroxide detoxification as the mechanism behind density-dependent mutation rate plasticity in microbial populations.

Overexpression of IkappaBalpha modulates NF-kappaB activation of inflammatory target gene expression

This study shows that overexpression of IκBα reduces inflammatory gene expression by inhibiting p65 promoter binding, even when p65 dynamics remain intact.

Variability of the innate immune response is globally constrained by transcriptional bursting

The paper analyzes TLR-induced gene expression variability using single-cell data and stochastic models, showing that gene response heterogeneity is captured by mean-variance relationships.

Single-cell imaging reveals non-cooperative and cooperative infection strategies of Listeria monocytogenes in macrophages

This study uses live-cell microscopy to show that L. monocytogenes infection of macrophages leads to heterogeneous outcomes, with non-cooperative bacterial behavior and population-level PrfA regulation affecting replication success.

Post-transcriptional regulatory feedback encodes JAK-STAT signal memory of interferon stimulation

The paper shows that interferon stimulation induces long-term STAT1 desensitization through post-transcriptional feedback, enabling cells to remember past stimulation and adjust future responses.

Heat shock response pathways regulate stimulus-specificity and sensitivity of NF-κB signalling to temperature stress

The paper shows that heat shock response pathways modulate NF-κB signaling specificity and sensitivity to temperature stress in breast cancer cells.

Macrophage-specific NF-kappa B activation dynamics can segregate inflammatory bowel disease patients

This paper uses dynamic NF-kappaB activation assays in macrophages to stratify IBD patients into distinct phenotypic groups based on their response to stimulation.