J. Steel

This paper shows that a single amino acid change in the PB1 protein of the pandemic H1N1 virus can create a live-attenuated vaccine with reduced pathogenicity and transmission.

This study identifies dysregulation of M segment gene expression, particularly M2 overexpression, as a key factor in avian influenza A virus restriction in mammalian hosts.

The paper quantifies incomplete influenza A virus genomes (IVGs) and shows they require complementation for replication, but spatial structure facilitates this process, supporting viral spread but not transmission.

This study identifies SREBP1-driven KRT80 upregulation as a mechanism promoting invasion in endocrine-resistant ERα breast cancer through cytoskeletal changes and increased tumor stiffness.