A. Cox

FicD regulates adaptation to the unfolded protein response in the murine liver.

This study shows FicD regulates UPR responses in the murine liver during mild stress but not chronic or acute UPR induction.

Unexpected delayed incursion of highly pathogenic avian influenza H5N1 (clade 2.3.4.4b) in the Antarctic region

The paper investigates the delayed incursion of H5N1 avian influenza in Antarctica by analyzing surveillance data from before confirmed cases.

Processing of the hepatitis E virus polyprotein can be mediated by a cellular protease

This paper investigates hepatitis E virus polyprotein processing and finds that it relies on host proteases rather than viral proteases for replication.

Pseudomonas aeruginosa Elicits Sustained IL-1β Upregulation in Alveolar Macrophages from Lung Transplant Recipients

This study shows that Pseudomonas aeruginosa and its dominant microbiota increase IL-1β production in alveolar macrophages from lung transplant recipients, which can be reduced by inflammasome inhibitors.

Dissecting the Genetic Architecture of Carbon Partitioning in Sorghum using Multiscale Phenotypes

This study identifies loci associated with carbon partitioning traits in sorghum using multiscale phenotypes and multivariate analysis, revealing pleiotropy and tradeoffs in carbon allocation.

A single amino acid substitution in PB1 of pandemic H1N1 with A/Ann Arbor/6/60 master donor virus mutations as a novel live-attenuated influenza virus vaccine

This paper shows that a single amino acid change in the PB1 protein of the pandemic H1N1 virus can create a live-attenuated vaccine with reduced pathogenicity and transmission.

G2 stem cells orchestrate time-directed, long-range coordination of calcium signaling during skin epidermal regeneration

The paper uses a new machine learning tool to analyze calcium signaling dynamics in epidermal stem cells during regeneration, revealing that G2 stem cells coordinate long-range signaling through gap junctions.

Nanopore sequencing methods detect cell-free DNA associated with minimal residual disease and central nervous system infiltration in pediatric Acute Lymphoblastic Leukemia

This paper develops a nanopore sequencing method to detect B-ALL-associated cell-free DNA in blood and CSF, enabling early detection of MRD and CNS infiltration in pediatric ALL patients.

SARS-COV-2 induced Diarrhea is inflammatory, Ca2+ Dependent and involves activation of calcium activated Cl channels

This study investigates the pathophysiology of SARS-CoV-2-induced diarrhea, showing it is inflammatory, calcium-dependent, and involves activation of calcium-activated chloride channels.

Leishmania infantum xenodiagnosis from vertically infected dogs reveals significant skin tropism

This study shows vertically infected dogs transmit Leishmania infantum to sand flies more effectively when they have moderate disease, with higher skin parasite loads correlating strongly with sand fly infection.

The D614G Mutation Enhances the Lysosomal Trafficking of SARS-CoV-2 Spike

This study shows the D614G mutation in SARS-CoV-2 spike enhances lysosomal trafficking and accumulation, contributing to increased infectivity and transmission.

Herpes Simplex Virus type 1 Inflammasome Activation in Human Macrophages is Dependent on NLRP3, ASC, and Caspase-1

This study shows HSV-1 activates inflammasomes in human macrophages via NLRP3, ASC, and caspase-1, but not AIM2 or IFI16, and the virus inhibits inflammasome activation through an NLRP3-specific mechanism.

Missense mutations in the MLKL brace region lead to lethal neonatal inflammation in mice and are present in high frequency in humans.

This study identifies a missense mutation in MLKL causing lethal neonatal inflammation in mice and links it to increased frequency in human autoinflammatory disease.

Fine-mapping of genetic loci driving spontaneous clearance of hepatitis C virus infection

This study fine-maps genetic loci associated with spontaneous clearance of hepatitis C virus infection, identifying a narrower region in the MHC locus and suggesting subtype-specific effects.