Diminished Immune Cell Adhesion in Hypoimmune ICAM-1 Knockout Pluripotent Stem Cells
S. Saha, W. J. Haynes, N. Del Rio, E. E. Young, J. Zhang, J. Seo, L. Huang, A. M. Holm, W. Blashka, L. Murphy, M. Scholz, A. Henrichs, J. Suresh Babu, J. Steill, R. E. Stewart, , M. E. Brown
This paper identifies ICAM-1 as a novel hypoimmune target in human pluripotent stem cells, showing that its knock-out reduces immune cell adhesion and enhances graft survival.
bioRxiv · Jun 7, 2024 · PreprintImmunology