M. Scholz

Neural Network-Assisted Humanization of COVID-19 Hamster scRNAseq Data Reveals Matching Severity States in Human Disease

This paper uses neural networks to match disease states between human and hamster COVID-19 scRNAseq data, finding similar cellular responses in specific cell types across species.

Characterization of Tryptophan Oxidation Affecting D1 Degradation by FtsH in the Photosystem II Quality Control of Chloroplasts

This study shows that Trp oxidation at the N-terminus of D1 protein enhances FtsH-mediated degradation during high-light stress in PSII repair.

Calredoxin regulates the chloroplast NADPH-dependent thioredoxin reductase in Chlamydomonas reinhardtii

The paper investigates the role of calredoxin (CRX) in regulating the chloroplast NADPH-dependent thioredoxin reductase (NTRC) in Chlamydomonas reinhardtii, showing that CRX controls redox balance and photosynthesis efficiency.

Automatically tracking feeding behavior in populations of foraging C. elegans

This paper develops PharaGlow, an imaging and analysis tool to track feeding and locomotion in large populations of unrestrained C. elegans with high-throughput and precision.

Algal photosystem I dimer and high resolution model of PSI:plastocyanin complex

The paper presents a cryo-EM structure of a homodimeric chloroplast PSI from Chlamydomonas reinhardtii, revealing its organization and interactions with plastocyanin and Lhca9.

A SARS-CoV-2 neutralizing antibody selected from COVID-19 patients by phage display is binding to the ACE2-RBD interface and is tolerant to most known recently emerging RBD mutations

The paper describes the selection of a SARS-CoV-2 neutralizing antibody from COVID-19 patients using phage display, showing it binds the ACE2-RBD interface and remains effective against emerging RBD mutations.

Altered N-glycan composition impacts flagella mediated adhesion in Chlamydomonas reinhardtii

This study shows that altered N-glycan composition in Chlamydomonas reinhardtii reduces flagella-mediated adhesion and surface binding.

Same same but different: a web-based deep learning application for the histopathologic distinction of cortical malformations

The paper trains a CNN to distinguish between FCD IIb and TSC using histopathologic images and develops a web app for classification.

Novel insights into N-glycan fucosylation and core xylosylation in C. reinhardtii

The paper identifies a second core xylosyltransferase (XylT1B) and a fucosyltransferase in C. reinhardtii, showing their roles in N-glycan core modifications through mutant analysis.

Chloroplasts Require Glutathione Reductase to Balance Reactive Oxygen Species and Maintain Efficient Photosynthesis

This study shows that glutathione reductase is essential for maintaining a reducing stromal glutathione redox potential in chloroplasts, which supports efficient photosynthesis and plant growth.

Tuning molecular motor transport through cytoskeletal filament network organization

This study examines how the organization of cytoskeletal filament networks affects myosin II motor transport dynamics, showing predictable changes based on network microstructure.

Studying vertical microbiome transmission from mothers to infants by strain-level metagenomic profiling

This study identifies vertically transmitted microbial strains from mothers to infants using strain-level metagenomic profiling and metatranscriptomics.