X. Qing

Macrophages undergo functionally significant reprogramming of nucleotide metabolism upon classical activation

This study identifies significant reprogramming of nucleotide metabolism in classically activated macrophages, revealing key regulatory mechanisms and functional consequences.

Activation-induced shift in nutrient preference and function-specific nutrient dependence in human neutrophils

This study shows that human neutrophils shift nutrient preference from glycogen to glucose upon activation, with function-specific metabolic dependencies.

IRE-1α is a key switch of pyroptosis and necroptosis in mice by dominating Gasdermin D

This study shows IRE-1α regulates both necroptosis and pyroptosis in mice by modulating GSDMD activity, with implications for therapeutic targeting in tissue injuries.

Preparation of functional IgY that potently neutralizes HIV-1 in TZM-bl Cell line

This paper describes the preparation of HIV-1-neutralizing IgY antibodies from chicken eggs and demonstrates their potent in vitro neutralizing activity against HIV-1 IIIB.

A chicken IgY can efficiently inhibit the entry and replication of SARS-CoV-2 by targeting the ACE2 binding domain in vitro

This paper demonstrates that a chicken-derived IgY antibody can inhibit SARS-CoV-2 entry and replication in vitro with high efficacy, outperforming remdesivir.

Oligonucleotide capture sequencing of the SARS-CoV-2 genome and subgenomic fragments from COVID-19 individuals

This study develops an oligonucleotide capture sequencing method to generate SARS-CoV-2 genomic and transcriptome sequences from clinical samples, revealing differential transcriptional activity and ORF10 expression.

Depression and Anxiety in Healthcare Staffs in A Tertiary University Hospital in Luoyang, Henan Province: A Cross-Sectional Observational Study

This study assesses depression and anxiety prevalence among healthcare staff in a Chinese hospital, identifying workplace violence and poor sleep as key risk factors.